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Non-DHFR-mediated effects of methotrexate in osteosarcoma cell lines: epigenetic alterations and enhanced cell differentiation

BACKGROUND: Methotrexate is an important chemotherapeutic drug widely known as an inhibitor of dihydrofolate reductase (DHFR) which inhibits the reduction of folic acid. DHFR-mediated effects are apparently responsible for its primary antineoplastic action. However, other non-DHFR-mediated effects o...

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Detalles Bibliográficos
Autores principales:	Sramek, Martin, Neradil, Jakub, Sterba, Jaroslav, Veselska, Renata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770555/ https://www.ncbi.nlm.nih.gov/pubmed/26929741 http://dx.doi.org/10.1186/s12935-016-0289-2

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