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Pediatric gliomatosis cerebri mimicking tubercular encephalitis
Gliomatosis cerebri (GC) is a diffuse infiltrating glial neoplasm of astrocytic origin. GC in children is rare and difficult to diagnose, often presenting with a variety of signs and symptoms that may mimic myriad conditions. We discuss here the presentation and diagnosis of GC in a child who was in...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770656/ https://www.ncbi.nlm.nih.gov/pubmed/26962350 http://dx.doi.org/10.4103/1817-1745.174430 |
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author | Singhal, Namit Agarwal, Vinay |
author_facet | Singhal, Namit Agarwal, Vinay |
author_sort | Singhal, Namit |
collection | PubMed |
description | Gliomatosis cerebri (GC) is a diffuse infiltrating glial neoplasm of astrocytic origin. GC in children is rare and difficult to diagnose, often presenting with a variety of signs and symptoms that may mimic myriad conditions. We discuss here the presentation and diagnosis of GC in a child who was initially treated on lines of tubercular encephalitis, with transient clinical relief and disappearance of enhancing component of the disease on magnetic resonance imaging. In this report, we highlight the limitations of clinical presentation and neuroimaging as well as the essential role of histological evaluation for the diagnosis of GC in children. Also is highlighted a more benign and protracted clinical course following radiotherapy in a subset of patients, with Ki index <10%, thereby stressing earliest possible diagnosis. A new prognostic classification can also be proposed for pediatric GC based on various parameters. Since these are rare cases, a combined effort is required for this. |
format | Online Article Text |
id | pubmed-4770656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47706562016-03-09 Pediatric gliomatosis cerebri mimicking tubercular encephalitis Singhal, Namit Agarwal, Vinay J Pediatr Neurosci Case Report Gliomatosis cerebri (GC) is a diffuse infiltrating glial neoplasm of astrocytic origin. GC in children is rare and difficult to diagnose, often presenting with a variety of signs and symptoms that may mimic myriad conditions. We discuss here the presentation and diagnosis of GC in a child who was initially treated on lines of tubercular encephalitis, with transient clinical relief and disappearance of enhancing component of the disease on magnetic resonance imaging. In this report, we highlight the limitations of clinical presentation and neuroimaging as well as the essential role of histological evaluation for the diagnosis of GC in children. Also is highlighted a more benign and protracted clinical course following radiotherapy in a subset of patients, with Ki index <10%, thereby stressing earliest possible diagnosis. A new prognostic classification can also be proposed for pediatric GC based on various parameters. Since these are rare cases, a combined effort is required for this. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4770656/ /pubmed/26962350 http://dx.doi.org/10.4103/1817-1745.174430 Text en Copyright: © Journal of Pediatric Neurosciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Singhal, Namit Agarwal, Vinay Pediatric gliomatosis cerebri mimicking tubercular encephalitis |
title | Pediatric gliomatosis cerebri mimicking tubercular encephalitis |
title_full | Pediatric gliomatosis cerebri mimicking tubercular encephalitis |
title_fullStr | Pediatric gliomatosis cerebri mimicking tubercular encephalitis |
title_full_unstemmed | Pediatric gliomatosis cerebri mimicking tubercular encephalitis |
title_short | Pediatric gliomatosis cerebri mimicking tubercular encephalitis |
title_sort | pediatric gliomatosis cerebri mimicking tubercular encephalitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770656/ https://www.ncbi.nlm.nih.gov/pubmed/26962350 http://dx.doi.org/10.4103/1817-1745.174430 |
work_keys_str_mv | AT singhalnamit pediatricgliomatosiscerebrimimickingtubercularencephalitis AT agarwalvinay pediatricgliomatosiscerebrimimickingtubercularencephalitis |