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Common antigens between hydatid cyst and cancers

BACKGROUND: Different research groups reported a negative correlation between cancers and parasitical infections. As an example, the prevalence of a hydatid cyst among patients with cancer was significantly lower than its prevalence among normal population. Tn antigens exist both in cancer and hydat...

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Autores principales: Daneshpour, Shima, Bahadoran, Mehran, Hejazi, Seyed Hossein, Eskandarian, Abas Ali, Mahmoudzadeh, Mehdi, Darani, Hossein Yousofi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770709/
https://www.ncbi.nlm.nih.gov/pubmed/26962511
http://dx.doi.org/10.4103/2277-9175.175242
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author Daneshpour, Shima
Bahadoran, Mehran
Hejazi, Seyed Hossein
Eskandarian, Abas Ali
Mahmoudzadeh, Mehdi
Darani, Hossein Yousofi
author_facet Daneshpour, Shima
Bahadoran, Mehran
Hejazi, Seyed Hossein
Eskandarian, Abas Ali
Mahmoudzadeh, Mehdi
Darani, Hossein Yousofi
author_sort Daneshpour, Shima
collection PubMed
description BACKGROUND: Different research groups reported a negative correlation between cancers and parasitical infections. As an example, the prevalence of a hydatid cyst among patients with cancer was significantly lower than its prevalence among normal population. Tn antigens exist both in cancer and hydatid cyst. This common antigen may be involved in the effect of parasite on cancer growth. So in this work, common antigens between hydatid cyst and cancers have been investigated. MATERIALS AND METHODS: Different hydatid cyst antigens including hydatid fluid, laminated and germinal layer antigens, and excretory secretory antigens of protoscolices were run in SDS PAGE and transferred to NCP paper. In western immunoblotting, those antigens were probed with sera of patients with different cancer and also sera of non-cancer patients. Also, cross reaction among excretory secretory products of cancer cells and antisera raised against different hydatid cyst antigen was investigated. RESULTS: In western immunoblotting, antisera raised against laminated and germinal layers of hydatid cyst reacted with excretory secretory products of cancer cells. Also, a reaction was detected between hydatid cyst antigens and sera of patients with some cancers. CONCLUSION: Results of this work emphasize existence of common antigens between hydatid cyst and cancers. More investigation about these common antigens is recommended.
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spelling pubmed-47707092016-03-09 Common antigens between hydatid cyst and cancers Daneshpour, Shima Bahadoran, Mehran Hejazi, Seyed Hossein Eskandarian, Abas Ali Mahmoudzadeh, Mehdi Darani, Hossein Yousofi Adv Biomed Res Original Article BACKGROUND: Different research groups reported a negative correlation between cancers and parasitical infections. As an example, the prevalence of a hydatid cyst among patients with cancer was significantly lower than its prevalence among normal population. Tn antigens exist both in cancer and hydatid cyst. This common antigen may be involved in the effect of parasite on cancer growth. So in this work, common antigens between hydatid cyst and cancers have been investigated. MATERIALS AND METHODS: Different hydatid cyst antigens including hydatid fluid, laminated and germinal layer antigens, and excretory secretory antigens of protoscolices were run in SDS PAGE and transferred to NCP paper. In western immunoblotting, those antigens were probed with sera of patients with different cancer and also sera of non-cancer patients. Also, cross reaction among excretory secretory products of cancer cells and antisera raised against different hydatid cyst antigen was investigated. RESULTS: In western immunoblotting, antisera raised against laminated and germinal layers of hydatid cyst reacted with excretory secretory products of cancer cells. Also, a reaction was detected between hydatid cyst antigens and sera of patients with some cancers. CONCLUSION: Results of this work emphasize existence of common antigens between hydatid cyst and cancers. More investigation about these common antigens is recommended. Medknow Publications & Media Pvt Ltd 2016-01-29 /pmc/articles/PMC4770709/ /pubmed/26962511 http://dx.doi.org/10.4103/2277-9175.175242 Text en Copyright: © 2016 Daneshpour. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Daneshpour, Shima
Bahadoran, Mehran
Hejazi, Seyed Hossein
Eskandarian, Abas Ali
Mahmoudzadeh, Mehdi
Darani, Hossein Yousofi
Common antigens between hydatid cyst and cancers
title Common antigens between hydatid cyst and cancers
title_full Common antigens between hydatid cyst and cancers
title_fullStr Common antigens between hydatid cyst and cancers
title_full_unstemmed Common antigens between hydatid cyst and cancers
title_short Common antigens between hydatid cyst and cancers
title_sort common antigens between hydatid cyst and cancers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770709/
https://www.ncbi.nlm.nih.gov/pubmed/26962511
http://dx.doi.org/10.4103/2277-9175.175242
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