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A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy
The alterations in carbohydrate metabolism that fuel tumor growth have been extensively studied. However, other metabolic pathways involved in malignant progression, demand further understanding. Here we describe a metabolic acyl-CoA synthetase/stearoyl-CoA desaturase ACSL/SCD network causing an epi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770732/ https://www.ncbi.nlm.nih.gov/pubmed/26451612 |
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author | Sánchez-Martínez, Ruth Cruz-Gil, Silvia de Cedrón, Marta Gómez Álvarez-Fernández, Mónica Vargas, Teodoro Molina, Susana García, Belén Herranz, Jesús Moreno-Rubio, Juan Reglero, Guillermo Pérez-Moreno, Mirna Feliu, Jaime Malumbres, Marcos de Molina, Ana Ramírez |
author_facet | Sánchez-Martínez, Ruth Cruz-Gil, Silvia de Cedrón, Marta Gómez Álvarez-Fernández, Mónica Vargas, Teodoro Molina, Susana García, Belén Herranz, Jesús Moreno-Rubio, Juan Reglero, Guillermo Pérez-Moreno, Mirna Feliu, Jaime Malumbres, Marcos de Molina, Ana Ramírez |
author_sort | Sánchez-Martínez, Ruth |
collection | PubMed |
description | The alterations in carbohydrate metabolism that fuel tumor growth have been extensively studied. However, other metabolic pathways involved in malignant progression, demand further understanding. Here we describe a metabolic acyl-CoA synthetase/stearoyl-CoA desaturase ACSL/SCD network causing an epithelial-mesenchymal transition (EMT) program that promotes migration and invasion of colon cancer cells. The mesenchymal phenotype produced upon overexpression of these enzymes is reverted through reactivation of AMPK signaling. Furthermore, this network expression correlates with poorer clinical outcome of stage-II colon cancer patients. Finally, combined treatment with chemical inhibitors of ACSL/SCD selectively decreases cancer cell viability without reducing normal cells viability. Thus, ACSL/SCD network stimulates colon cancer progression through conferring increased energetic capacity and invasive and migratory properties to cancer cells, and might represent a new therapeutic opportunity for colon cancer treatment. |
format | Online Article Text |
id | pubmed-4770732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-47707322016-03-21 A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy Sánchez-Martínez, Ruth Cruz-Gil, Silvia de Cedrón, Marta Gómez Álvarez-Fernández, Mónica Vargas, Teodoro Molina, Susana García, Belén Herranz, Jesús Moreno-Rubio, Juan Reglero, Guillermo Pérez-Moreno, Mirna Feliu, Jaime Malumbres, Marcos de Molina, Ana Ramírez Oncotarget Research Paper The alterations in carbohydrate metabolism that fuel tumor growth have been extensively studied. However, other metabolic pathways involved in malignant progression, demand further understanding. Here we describe a metabolic acyl-CoA synthetase/stearoyl-CoA desaturase ACSL/SCD network causing an epithelial-mesenchymal transition (EMT) program that promotes migration and invasion of colon cancer cells. The mesenchymal phenotype produced upon overexpression of these enzymes is reverted through reactivation of AMPK signaling. Furthermore, this network expression correlates with poorer clinical outcome of stage-II colon cancer patients. Finally, combined treatment with chemical inhibitors of ACSL/SCD selectively decreases cancer cell viability without reducing normal cells viability. Thus, ACSL/SCD network stimulates colon cancer progression through conferring increased energetic capacity and invasive and migratory properties to cancer cells, and might represent a new therapeutic opportunity for colon cancer treatment. Impact Journals LLC 2015-10-05 /pmc/articles/PMC4770732/ /pubmed/26451612 Text en Copyright: © 2015 Sánchez-Martínez et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Sánchez-Martínez, Ruth Cruz-Gil, Silvia de Cedrón, Marta Gómez Álvarez-Fernández, Mónica Vargas, Teodoro Molina, Susana García, Belén Herranz, Jesús Moreno-Rubio, Juan Reglero, Guillermo Pérez-Moreno, Mirna Feliu, Jaime Malumbres, Marcos de Molina, Ana Ramírez A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy |
title | A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy |
title_full | A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy |
title_fullStr | A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy |
title_full_unstemmed | A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy |
title_short | A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy |
title_sort | link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770732/ https://www.ncbi.nlm.nih.gov/pubmed/26451612 |
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