Deletion of cyclooxygenase-2 inhibits K-ras–induced lung carcinogenesis

The purpose of this study was to identify the role COX-2 plays in K-ras–induced lung carcinogenesis. We crossed COX-2–homozygous knockout mice with K-ras(LA1) (G12D) expressing mice to obtain COX-2–deficient mice with K-ras expression (K-ras/COX-2(−/−) mice) and COX-2 wild type mice with K-ras expre...

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Detalles Bibliográficos
Autores principales: Pan, Yong, Jiang, Yan, Tan, Lin, K. Ravoori, Murali, Gagea, Mihai, Vikas Kundra, Vikus, Fischer, Susan M., Yang, Peiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770739/
https://www.ncbi.nlm.nih.gov/pubmed/26452035

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