The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling

Previously we reported that valproic acid (VPA) acts in synergy with GOS to enhance cell death in human DU145 cells. However, the underlying mechanism remains elusive. In this study, we observed that such synergistic cytotoxicity of GOS and VPA could be extended to human A375, HeLa, and PC-3 cancer...

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Detalles Bibliográficos
Autores principales: Zhao, Gao-Xiang, Xu, Li-Hui, Pan, Hao, Lin, Qiu-Ru, Huang, Mei-Yun, Cai, Ji-Ye, Ouyang, Dong-Yun, He, Xian-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770749/
https://www.ncbi.nlm.nih.gov/pubmed/26517515

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