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The Role of Detraining in Tendon Mechanobiology

Introduction: Several conditions such as training, aging, estrogen deficiency and drugs could affect the biological and anatomo-physiological characteristics of the tendon. Additionally, recent preclinical and clinical studies examined the effect of detraining on tendon, showing alterations in its s...

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Autores principales: Frizziero, Antonio, Salamanna, Francesca, Della Bella, Elena, Vittadini, Filippo, Gasparre, Giuseppe, Nicoli Aldini, Nicolò, Masiero, Stefano, Fini, Milena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770795/
https://www.ncbi.nlm.nih.gov/pubmed/26973517
http://dx.doi.org/10.3389/fnagi.2016.00043
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author Frizziero, Antonio
Salamanna, Francesca
Della Bella, Elena
Vittadini, Filippo
Gasparre, Giuseppe
Nicoli Aldini, Nicolò
Masiero, Stefano
Fini, Milena
author_facet Frizziero, Antonio
Salamanna, Francesca
Della Bella, Elena
Vittadini, Filippo
Gasparre, Giuseppe
Nicoli Aldini, Nicolò
Masiero, Stefano
Fini, Milena
author_sort Frizziero, Antonio
collection PubMed
description Introduction: Several conditions such as training, aging, estrogen deficiency and drugs could affect the biological and anatomo-physiological characteristics of the tendon. Additionally, recent preclinical and clinical studies examined the effect of detraining on tendon, showing alterations in its structure and morphology and in tenocyte mechanobiology. However, few data evaluated the importance that cessation of training might have on tendon. Basically, we do not fully understand how tendons react to a phase of training followed by sudden detraining. Therefore, within this review, we summarize the studies where tendon detraining was examined. Materials and Methods: A descriptive systematic literature review was carried out by searching three databases (PubMed, Scopus and Web of Knowledge) on tendon detraining. Original articles in English from 2000 to 2015 were included. In addition, the search was extended to the reference lists of the selected articles. A public reference manager (www.mendeley.com) was adopted to remove duplicate articles. Results: An initial literature search yielded 134 references (www.pubmed.org: 53; www.scopus.com: 11; www.webofknowledge.com: 70). Fifteen publications were extracted based on the title for further analysis by two independent reviewers. Abstracts and complete articles were after that reviewed to evaluate if they met inclusion criteria. Conclusions: The revised literature comprised four clinical studies and an in vitro and three in vivo reports. Overall, the results showed that tendon structure and properties after detraining are compromised, with an alteration in the tissue structural organization and mechanical properties. Clinical studies usually showed a lesser extent of tendon alterations, probably because preclinical studies permit an in-depth evaluation of tendon modifications, which is hard to perform in human subjects. In conclusion, after a period of sudden detraining (e.g., after an injury), physical activity should be taken with caution, following a targeted rehabilitation program. However, further research should be performed to fully understand the effect of sudden detraining on tendons.
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spelling pubmed-47707952016-03-11 The Role of Detraining in Tendon Mechanobiology Frizziero, Antonio Salamanna, Francesca Della Bella, Elena Vittadini, Filippo Gasparre, Giuseppe Nicoli Aldini, Nicolò Masiero, Stefano Fini, Milena Front Aging Neurosci Neuroscience Introduction: Several conditions such as training, aging, estrogen deficiency and drugs could affect the biological and anatomo-physiological characteristics of the tendon. Additionally, recent preclinical and clinical studies examined the effect of detraining on tendon, showing alterations in its structure and morphology and in tenocyte mechanobiology. However, few data evaluated the importance that cessation of training might have on tendon. Basically, we do not fully understand how tendons react to a phase of training followed by sudden detraining. Therefore, within this review, we summarize the studies where tendon detraining was examined. Materials and Methods: A descriptive systematic literature review was carried out by searching three databases (PubMed, Scopus and Web of Knowledge) on tendon detraining. Original articles in English from 2000 to 2015 were included. In addition, the search was extended to the reference lists of the selected articles. A public reference manager (www.mendeley.com) was adopted to remove duplicate articles. Results: An initial literature search yielded 134 references (www.pubmed.org: 53; www.scopus.com: 11; www.webofknowledge.com: 70). Fifteen publications were extracted based on the title for further analysis by two independent reviewers. Abstracts and complete articles were after that reviewed to evaluate if they met inclusion criteria. Conclusions: The revised literature comprised four clinical studies and an in vitro and three in vivo reports. Overall, the results showed that tendon structure and properties after detraining are compromised, with an alteration in the tissue structural organization and mechanical properties. Clinical studies usually showed a lesser extent of tendon alterations, probably because preclinical studies permit an in-depth evaluation of tendon modifications, which is hard to perform in human subjects. In conclusion, after a period of sudden detraining (e.g., after an injury), physical activity should be taken with caution, following a targeted rehabilitation program. However, further research should be performed to fully understand the effect of sudden detraining on tendons. Frontiers Media S.A. 2016-02-29 /pmc/articles/PMC4770795/ /pubmed/26973517 http://dx.doi.org/10.3389/fnagi.2016.00043 Text en Copyright © 2016 Frizziero, Salamanna, Della Bella, Vittadini, Gasparre, Nicoli Aldini, Masiero and Fini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Frizziero, Antonio
Salamanna, Francesca
Della Bella, Elena
Vittadini, Filippo
Gasparre, Giuseppe
Nicoli Aldini, Nicolò
Masiero, Stefano
Fini, Milena
The Role of Detraining in Tendon Mechanobiology
title The Role of Detraining in Tendon Mechanobiology
title_full The Role of Detraining in Tendon Mechanobiology
title_fullStr The Role of Detraining in Tendon Mechanobiology
title_full_unstemmed The Role of Detraining in Tendon Mechanobiology
title_short The Role of Detraining in Tendon Mechanobiology
title_sort role of detraining in tendon mechanobiology
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770795/
https://www.ncbi.nlm.nih.gov/pubmed/26973517
http://dx.doi.org/10.3389/fnagi.2016.00043
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