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Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents

We sought to determine whether the orexigenic hormone, ghrelin, is involved in the intrinsic regulation of food choice in rats. Ghrelin would seem suited to serve such a role given that it signals hunger information from the stomach to brain areas important for feeding control, including the hypotha...

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Autores principales: Schéle, Erik, Bake, Tina, Rabasa, Cristina, Dickson, Suzanne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771210/
https://www.ncbi.nlm.nih.gov/pubmed/26925974
http://dx.doi.org/10.1371/journal.pone.0149456
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author Schéle, Erik
Bake, Tina
Rabasa, Cristina
Dickson, Suzanne L.
author_facet Schéle, Erik
Bake, Tina
Rabasa, Cristina
Dickson, Suzanne L.
author_sort Schéle, Erik
collection PubMed
description We sought to determine whether the orexigenic hormone, ghrelin, is involved in the intrinsic regulation of food choice in rats. Ghrelin would seem suited to serve such a role given that it signals hunger information from the stomach to brain areas important for feeding control, including the hypothalamus and reward system (e.g. ventral tegmental area, VTA). Thus, in rats offered a choice of palatable foods (sucrose pellets and lard) superimposed on regular chow for 2 weeks, we explored whether acute central delivery of ghrelin (intracerebroventricular (ICV) or intra-VTA) is able to redirect their dietary choice. The major unexpected finding is that, in rats with high baseline lard intake, acute ICV ghrelin injection increased their chow intake over 3-fold, relative to vehicle-injected controls, measured at both 3 hr and 6 hr after injection. Similar effects were observed when ghrelin was delivered to the VTA, thereby identifying the VTA as a likely contributing neurobiological substrate for these effects. We also explored food choice after an overnight fast, when endogenous ghrelin levels are elevated, and found similar effects of dietary choice to those described for ghrelin. These effects of fasting on food choice were suppressed in models of suppressed ghrelin signaling (i.e. peripheral injection of a ghrelin receptor antagonist to rats and ghrelin receptor (GHSR) knock-out mice), implicating a role for endogenous ghrelin in the changes in food choice that occur after an overnight fast. Thus, in line with its role as a gut-brain hunger hormone, ghrelin appears to be able to acutely alter food choice, with notable effects to promote “healthy” chow intake, and identify the VTA as a likely contributing neurobiological substrate for these effects.
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spelling pubmed-47712102016-03-07 Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents Schéle, Erik Bake, Tina Rabasa, Cristina Dickson, Suzanne L. PLoS One Research Article We sought to determine whether the orexigenic hormone, ghrelin, is involved in the intrinsic regulation of food choice in rats. Ghrelin would seem suited to serve such a role given that it signals hunger information from the stomach to brain areas important for feeding control, including the hypothalamus and reward system (e.g. ventral tegmental area, VTA). Thus, in rats offered a choice of palatable foods (sucrose pellets and lard) superimposed on regular chow for 2 weeks, we explored whether acute central delivery of ghrelin (intracerebroventricular (ICV) or intra-VTA) is able to redirect their dietary choice. The major unexpected finding is that, in rats with high baseline lard intake, acute ICV ghrelin injection increased their chow intake over 3-fold, relative to vehicle-injected controls, measured at both 3 hr and 6 hr after injection. Similar effects were observed when ghrelin was delivered to the VTA, thereby identifying the VTA as a likely contributing neurobiological substrate for these effects. We also explored food choice after an overnight fast, when endogenous ghrelin levels are elevated, and found similar effects of dietary choice to those described for ghrelin. These effects of fasting on food choice were suppressed in models of suppressed ghrelin signaling (i.e. peripheral injection of a ghrelin receptor antagonist to rats and ghrelin receptor (GHSR) knock-out mice), implicating a role for endogenous ghrelin in the changes in food choice that occur after an overnight fast. Thus, in line with its role as a gut-brain hunger hormone, ghrelin appears to be able to acutely alter food choice, with notable effects to promote “healthy” chow intake, and identify the VTA as a likely contributing neurobiological substrate for these effects. Public Library of Science 2016-02-29 /pmc/articles/PMC4771210/ /pubmed/26925974 http://dx.doi.org/10.1371/journal.pone.0149456 Text en © 2016 Schéle et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Schéle, Erik
Bake, Tina
Rabasa, Cristina
Dickson, Suzanne L.
Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents
title Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents
title_full Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents
title_fullStr Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents
title_full_unstemmed Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents
title_short Centrally Administered Ghrelin Acutely Influences Food Choice in Rodents
title_sort centrally administered ghrelin acutely influences food choice in rodents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771210/
https://www.ncbi.nlm.nih.gov/pubmed/26925974
http://dx.doi.org/10.1371/journal.pone.0149456
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