Cargando…
Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness
Epicardial adipose tissue thickness (EATT) is suggested as a novel marker of subclinical atherosclerosis. Despite increased carotid intima-media thickness (CIMT) in autosomal dominant polycystic kidney disease (ADPKD) patients, the extent of the relationship between CIMT and EATT is unknown. The mai...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771685/ https://www.ncbi.nlm.nih.gov/pubmed/27026905 http://dx.doi.org/10.1186/s40064-016-1871-8 |
_version_ | 1782418423390666752 |
---|---|
author | Sag, Saim Yildiz, Abdulmecit Gullulu, Sumeyye Gungoren, Fatih Ozdemir, Bulent Cegilli, Ercan Oruc, Aysegul Ersoy, Alparslan Gullulu, Mustafa |
author_facet | Sag, Saim Yildiz, Abdulmecit Gullulu, Sumeyye Gungoren, Fatih Ozdemir, Bulent Cegilli, Ercan Oruc, Aysegul Ersoy, Alparslan Gullulu, Mustafa |
author_sort | Sag, Saim |
collection | PubMed |
description | Epicardial adipose tissue thickness (EATT) is suggested as a novel marker of subclinical atherosclerosis. Despite increased carotid intima-media thickness (CIMT) in autosomal dominant polycystic kidney disease (ADPKD) patients, the extent of the relationship between CIMT and EATT is unknown. The main purpose of our study was to evaluate the relation between EATT and CIMT in normotensive ADPKD patients with well-preserved renal function. Fifty-five normotensive ADPKD patients with normal renal function and 50 healthy control subjects were included in the study. EATT and CIMT were measured by echocardiography in all subjects. Correlation between EATT and CIMT was evaluated in ADPKD patients, while multivariate linear regression analysis was performed to determine factors predicting EATT and CIMT. ADPKD patients had significantly higher levels CIMT [0.7 (0.4–1.2) vs. 0.5 (0.4–0.8) mm, p < 0.001] and EATT (6.8 ± 2.7 vs. 4.8 ± 1.2 mm, p < 0.001) as compared with control subjects. Significant positive correlation was found between EATT and CIMT (r = 0.58, p < 0.001). Higher CRP levels (OR 54.7, 95 % CI 37.44–72.01, p < 0.001) and having ADPKD (OR 10.2, 95 % CI 2.53–17.86, p = 0.01) were the only independent factors associated with a higher EATT. A higher age (OR 0.35, 95 % CI −0.02 to 0.71, p = 0.06) tended to be independently associated with a higher EATT. In conclusion, our findings suggest that EATT, being simply measured by echocardiography and correlated with CIMT, can be used to detect subclinical atherosclerosis in normotensive ADPKD patients. |
format | Online Article Text |
id | pubmed-4771685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-47716852016-03-29 Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness Sag, Saim Yildiz, Abdulmecit Gullulu, Sumeyye Gungoren, Fatih Ozdemir, Bulent Cegilli, Ercan Oruc, Aysegul Ersoy, Alparslan Gullulu, Mustafa Springerplus Research Epicardial adipose tissue thickness (EATT) is suggested as a novel marker of subclinical atherosclerosis. Despite increased carotid intima-media thickness (CIMT) in autosomal dominant polycystic kidney disease (ADPKD) patients, the extent of the relationship between CIMT and EATT is unknown. The main purpose of our study was to evaluate the relation between EATT and CIMT in normotensive ADPKD patients with well-preserved renal function. Fifty-five normotensive ADPKD patients with normal renal function and 50 healthy control subjects were included in the study. EATT and CIMT were measured by echocardiography in all subjects. Correlation between EATT and CIMT was evaluated in ADPKD patients, while multivariate linear regression analysis was performed to determine factors predicting EATT and CIMT. ADPKD patients had significantly higher levels CIMT [0.7 (0.4–1.2) vs. 0.5 (0.4–0.8) mm, p < 0.001] and EATT (6.8 ± 2.7 vs. 4.8 ± 1.2 mm, p < 0.001) as compared with control subjects. Significant positive correlation was found between EATT and CIMT (r = 0.58, p < 0.001). Higher CRP levels (OR 54.7, 95 % CI 37.44–72.01, p < 0.001) and having ADPKD (OR 10.2, 95 % CI 2.53–17.86, p = 0.01) were the only independent factors associated with a higher EATT. A higher age (OR 0.35, 95 % CI −0.02 to 0.71, p = 0.06) tended to be independently associated with a higher EATT. In conclusion, our findings suggest that EATT, being simply measured by echocardiography and correlated with CIMT, can be used to detect subclinical atherosclerosis in normotensive ADPKD patients. Springer International Publishing 2016-02-29 /pmc/articles/PMC4771685/ /pubmed/27026905 http://dx.doi.org/10.1186/s40064-016-1871-8 Text en © Sag et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Sag, Saim Yildiz, Abdulmecit Gullulu, Sumeyye Gungoren, Fatih Ozdemir, Bulent Cegilli, Ercan Oruc, Aysegul Ersoy, Alparslan Gullulu, Mustafa Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness |
title | Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness |
title_full | Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness |
title_fullStr | Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness |
title_full_unstemmed | Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness |
title_short | Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness |
title_sort | early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771685/ https://www.ncbi.nlm.nih.gov/pubmed/27026905 http://dx.doi.org/10.1186/s40064-016-1871-8 |
work_keys_str_mv | AT sagsaim earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness AT yildizabdulmecit earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness AT gullulusumeyye earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness AT gungorenfatih earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness AT ozdemirbulent earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness AT cegilliercan earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness AT orucaysegul earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness AT ersoyalparslan earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness AT gullulumustafa earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness |