Cargando…

Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness

Epicardial adipose tissue thickness (EATT) is suggested as a novel marker of subclinical atherosclerosis. Despite increased carotid intima-media thickness (CIMT) in autosomal dominant polycystic kidney disease (ADPKD) patients, the extent of the relationship between CIMT and EATT is unknown. The mai...

Descripción completa

Detalles Bibliográficos
Autores principales: Sag, Saim, Yildiz, Abdulmecit, Gullulu, Sumeyye, Gungoren, Fatih, Ozdemir, Bulent, Cegilli, Ercan, Oruc, Aysegul, Ersoy, Alparslan, Gullulu, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771685/
https://www.ncbi.nlm.nih.gov/pubmed/27026905
http://dx.doi.org/10.1186/s40064-016-1871-8
_version_ 1782418423390666752
author Sag, Saim
Yildiz, Abdulmecit
Gullulu, Sumeyye
Gungoren, Fatih
Ozdemir, Bulent
Cegilli, Ercan
Oruc, Aysegul
Ersoy, Alparslan
Gullulu, Mustafa
author_facet Sag, Saim
Yildiz, Abdulmecit
Gullulu, Sumeyye
Gungoren, Fatih
Ozdemir, Bulent
Cegilli, Ercan
Oruc, Aysegul
Ersoy, Alparslan
Gullulu, Mustafa
author_sort Sag, Saim
collection PubMed
description Epicardial adipose tissue thickness (EATT) is suggested as a novel marker of subclinical atherosclerosis. Despite increased carotid intima-media thickness (CIMT) in autosomal dominant polycystic kidney disease (ADPKD) patients, the extent of the relationship between CIMT and EATT is unknown. The main purpose of our study was to evaluate the relation between EATT and CIMT in normotensive ADPKD patients with well-preserved renal function. Fifty-five normotensive ADPKD patients with normal renal function and 50 healthy control subjects were included in the study. EATT and CIMT were measured by echocardiography in all subjects. Correlation between EATT and CIMT was evaluated in ADPKD patients, while multivariate linear regression analysis was performed to determine factors predicting EATT and CIMT. ADPKD patients had significantly higher levels CIMT [0.7 (0.4–1.2) vs. 0.5 (0.4–0.8) mm, p < 0.001] and EATT (6.8 ± 2.7 vs. 4.8 ± 1.2 mm, p < 0.001) as compared with control subjects. Significant positive correlation was found between EATT and CIMT (r = 0.58, p < 0.001). Higher CRP levels (OR 54.7, 95 % CI 37.44–72.01, p < 0.001) and having ADPKD (OR 10.2, 95 % CI 2.53–17.86, p = 0.01) were the only independent factors associated with a higher EATT. A higher age (OR 0.35, 95 % CI −0.02 to 0.71, p = 0.06) tended to be independently associated with a higher EATT. In conclusion, our findings suggest that EATT, being simply measured by echocardiography and correlated with CIMT, can be used to detect subclinical atherosclerosis in normotensive ADPKD patients.
format Online
Article
Text
id pubmed-4771685
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-47716852016-03-29 Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness Sag, Saim Yildiz, Abdulmecit Gullulu, Sumeyye Gungoren, Fatih Ozdemir, Bulent Cegilli, Ercan Oruc, Aysegul Ersoy, Alparslan Gullulu, Mustafa Springerplus Research Epicardial adipose tissue thickness (EATT) is suggested as a novel marker of subclinical atherosclerosis. Despite increased carotid intima-media thickness (CIMT) in autosomal dominant polycystic kidney disease (ADPKD) patients, the extent of the relationship between CIMT and EATT is unknown. The main purpose of our study was to evaluate the relation between EATT and CIMT in normotensive ADPKD patients with well-preserved renal function. Fifty-five normotensive ADPKD patients with normal renal function and 50 healthy control subjects were included in the study. EATT and CIMT were measured by echocardiography in all subjects. Correlation between EATT and CIMT was evaluated in ADPKD patients, while multivariate linear regression analysis was performed to determine factors predicting EATT and CIMT. ADPKD patients had significantly higher levels CIMT [0.7 (0.4–1.2) vs. 0.5 (0.4–0.8) mm, p < 0.001] and EATT (6.8 ± 2.7 vs. 4.8 ± 1.2 mm, p < 0.001) as compared with control subjects. Significant positive correlation was found between EATT and CIMT (r = 0.58, p < 0.001). Higher CRP levels (OR 54.7, 95 % CI 37.44–72.01, p < 0.001) and having ADPKD (OR 10.2, 95 % CI 2.53–17.86, p = 0.01) were the only independent factors associated with a higher EATT. A higher age (OR 0.35, 95 % CI −0.02 to 0.71, p = 0.06) tended to be independently associated with a higher EATT. In conclusion, our findings suggest that EATT, being simply measured by echocardiography and correlated with CIMT, can be used to detect subclinical atherosclerosis in normotensive ADPKD patients. Springer International Publishing 2016-02-29 /pmc/articles/PMC4771685/ /pubmed/27026905 http://dx.doi.org/10.1186/s40064-016-1871-8 Text en © Sag et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Sag, Saim
Yildiz, Abdulmecit
Gullulu, Sumeyye
Gungoren, Fatih
Ozdemir, Bulent
Cegilli, Ercan
Oruc, Aysegul
Ersoy, Alparslan
Gullulu, Mustafa
Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness
title Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness
title_full Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness
title_fullStr Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness
title_full_unstemmed Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness
title_short Early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness
title_sort early atherosclerosis in normotensive patients with autosomal dominant polycystic kidney disease: the relation between epicardial adipose tissue thickness and carotid intima-media thickness
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771685/
https://www.ncbi.nlm.nih.gov/pubmed/27026905
http://dx.doi.org/10.1186/s40064-016-1871-8
work_keys_str_mv AT sagsaim earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness
AT yildizabdulmecit earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness
AT gullulusumeyye earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness
AT gungorenfatih earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness
AT ozdemirbulent earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness
AT cegilliercan earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness
AT orucaysegul earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness
AT ersoyalparslan earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness
AT gullulumustafa earlyatherosclerosisinnormotensivepatientswithautosomaldominantpolycystickidneydiseasetherelationbetweenepicardialadiposetissuethicknessandcarotidintimamediathickness