Moderate Increase of Indoxyl Sulfate Promotes Monocyte Transition into Profibrotic Macrophages

OBJECTIVE: The uremic toxin Indoxyl-3-sulphate (IS), a ligand of Aryl hydrocarbon Receptor (AhR), raises in blood during early renal dysfunction as a consequence of tubular damage, which may be present even when eGFR is normal or only moderately reduced, and promotes cardiovascular damage and monocy...

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Detalles Bibliográficos
Autores principales: Barisione, Chiara, Garibaldi, Silvano, Furfaro, Anna Lisa, Nitti, Mariapaola, Palmieri, Daniela, Passalacqua, Mario, Garuti, Anna, Verzola, Daniela, Parodi, Alessia, Ameri, Pietro, Altieri, Paola, Fabbi, Patrizia, Ferrar, Pier Francesco, Brunelli, Claudio, Arsenescu, Violeta, Balbi, Manrico, Palombo, Domenico, Ghigliotti, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771744/
https://www.ncbi.nlm.nih.gov/pubmed/26925780
http://dx.doi.org/10.1371/journal.pone.0149276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771744/
https://www.ncbi.nlm.nih.gov/pubmed/26925780
http://dx.doi.org/10.1371/journal.pone.0149276

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