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Potential Anti-Atherosclerotic Properties of Astaxanthin
Astaxanthin is a naturally occurring red carotenoid pigment classified as a xanthophyll, found in microalgae and seafood such as salmon, trout, and shrimp. This review focuses on astaxanthin as a bioactive compound and outlines the evidence associated with its potential role in the prevention of ath...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771988/ https://www.ncbi.nlm.nih.gov/pubmed/26861359 http://dx.doi.org/10.3390/md14020035 |
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author | Kishimoto, Yoshimi Yoshida, Hiroshi Kondo, Kazuo |
author_facet | Kishimoto, Yoshimi Yoshida, Hiroshi Kondo, Kazuo |
author_sort | Kishimoto, Yoshimi |
collection | PubMed |
description | Astaxanthin is a naturally occurring red carotenoid pigment classified as a xanthophyll, found in microalgae and seafood such as salmon, trout, and shrimp. This review focuses on astaxanthin as a bioactive compound and outlines the evidence associated with its potential role in the prevention of atherosclerosis. Astaxanthin has a unique molecular structure that is responsible for its powerful antioxidant activities by quenching singlet oxygen and scavenging free radicals. Astaxanthin has been reported to inhibit low-density lipoprotein (LDL) oxidation and to increase high-density lipoprotein (HDL)-cholesterol and adiponectin levels in clinical studies. Accumulating evidence suggests that astaxanthin could exert preventive actions against atherosclerotic cardiovascular disease (CVD) via its potential to improve oxidative stress, inflammation, lipid metabolism, and glucose metabolism. In addition to identifying mechanisms of astaxanthin bioactivity by basic research, much more epidemiological and clinical evidence linking reduced CVD risk with dietary astaxanthin intake is needed. |
format | Online Article Text |
id | pubmed-4771988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-47719882016-03-08 Potential Anti-Atherosclerotic Properties of Astaxanthin Kishimoto, Yoshimi Yoshida, Hiroshi Kondo, Kazuo Mar Drugs Review Astaxanthin is a naturally occurring red carotenoid pigment classified as a xanthophyll, found in microalgae and seafood such as salmon, trout, and shrimp. This review focuses on astaxanthin as a bioactive compound and outlines the evidence associated with its potential role in the prevention of atherosclerosis. Astaxanthin has a unique molecular structure that is responsible for its powerful antioxidant activities by quenching singlet oxygen and scavenging free radicals. Astaxanthin has been reported to inhibit low-density lipoprotein (LDL) oxidation and to increase high-density lipoprotein (HDL)-cholesterol and adiponectin levels in clinical studies. Accumulating evidence suggests that astaxanthin could exert preventive actions against atherosclerotic cardiovascular disease (CVD) via its potential to improve oxidative stress, inflammation, lipid metabolism, and glucose metabolism. In addition to identifying mechanisms of astaxanthin bioactivity by basic research, much more epidemiological and clinical evidence linking reduced CVD risk with dietary astaxanthin intake is needed. MDPI 2016-02-05 /pmc/articles/PMC4771988/ /pubmed/26861359 http://dx.doi.org/10.3390/md14020035 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kishimoto, Yoshimi Yoshida, Hiroshi Kondo, Kazuo Potential Anti-Atherosclerotic Properties of Astaxanthin |
title | Potential Anti-Atherosclerotic Properties of Astaxanthin |
title_full | Potential Anti-Atherosclerotic Properties of Astaxanthin |
title_fullStr | Potential Anti-Atherosclerotic Properties of Astaxanthin |
title_full_unstemmed | Potential Anti-Atherosclerotic Properties of Astaxanthin |
title_short | Potential Anti-Atherosclerotic Properties of Astaxanthin |
title_sort | potential anti-atherosclerotic properties of astaxanthin |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771988/ https://www.ncbi.nlm.nih.gov/pubmed/26861359 http://dx.doi.org/10.3390/md14020035 |
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