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Epigenetic modification of PKMζ rescues aging-related cognitive impairment

Cognition is impacted by aging. However, the mechanisms that underlie aging-associated cognitive impairment are unclear. Here we showed that cognitive decline in aged rats was associated with changes in DNA methylation of protein kinase Mζ (PKMζ) in the prelimbic cortex (PrL). PKMζ is a crucial mole...

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Detalles Bibliográficos
Autores principales:	Chen, Chen, Meng, Shi-Qiu, Xue, Yan-Xue, Han, Ying, Sun, Cheng-Yu, Deng, Jia-Hui, Chen, Na, Bao, Yan-Ping, Zhang, Fei-Long, Cao, Lin-Lin, Zhu, Wei-Guo, Shi, Jie, Song, Wei-Hong, Lu, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772003/ https://www.ncbi.nlm.nih.gov/pubmed/26926225 http://dx.doi.org/10.1038/srep22096

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