Cargando…
Significant impact of miRNA–target gene networks on genetics of human complex traits
The impact of microRNA (miRNA) on the genetics of human complex traits, especially in the context of miRNA-target gene networks, has not been fully assessed. Here, we developed a novel analytical method, MIGWAS, to comprehensively evaluate enrichment of genome-wide association study (GWAS) signals i...
Autores principales: | Okada, Yukinori, Muramatsu, Tomoki, Suita, Naomasa, Kanai, Masahiro, Kawakami, Eiryo, Iotchkova, Valentina, Soranzo, Nicole, Inazawa, Johji, Tanaka, Toshihiro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772006/ https://www.ncbi.nlm.nih.gov/pubmed/26927695 http://dx.doi.org/10.1038/srep22223 |
Ejemplares similares
-
Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set
por: Kanai, Masahiro, et al.
Publicado: (2016) -
Massive computational identification of somatic variants in exonic splicing enhancers using The Cancer Genome Atlas
por: Tanimoto, Kousuke, et al.
Publicado: (2019) -
Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma
por: Sakha, Sujata, et al.
Publicado: (2016) -
Identification and characterization of transforming growth factor beta‐induced in circulating tumor cell subline from pancreatic cancer cell line
por: Sato, Taku, et al.
Publicado: (2018) -
Concurrent targeting of MAP3K3 and BRD4 by miR-3140-3p overcomes acquired resistance to BET inhibitors in neuroblastoma cells
por: Liu, Chang, et al.
Publicado: (2021)