Cargando…
Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women
Wheat bran, and especially wheat aleurone fraction, are concentrated sources of a wide range of components which may contribute to the health benefits associated with higher consumption of whole-grain foods. This study used NMR metabolomics to evaluate urine samples from baseline at one and two hour...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772058/ https://www.ncbi.nlm.nih.gov/pubmed/26901221 http://dx.doi.org/10.3390/nu8020096 |
_version_ | 1782418498785378304 |
---|---|
author | Garg, Ramandeep Brennan, Lorraine Price, Ruth K. Wallace, Julie M. W. Strain, J. J. Gibney, Mike J. Shewry, Peter R. Ward, Jane L. Garg, Lalit Welch, Robert W. |
author_facet | Garg, Ramandeep Brennan, Lorraine Price, Ruth K. Wallace, Julie M. W. Strain, J. J. Gibney, Mike J. Shewry, Peter R. Ward, Jane L. Garg, Lalit Welch, Robert W. |
author_sort | Garg, Ramandeep |
collection | PubMed |
description | Wheat bran, and especially wheat aleurone fraction, are concentrated sources of a wide range of components which may contribute to the health benefits associated with higher consumption of whole-grain foods. This study used NMR metabolomics to evaluate urine samples from baseline at one and two hours postprandially, following the consumption of minimally processed bran, aleurone or control by 14 participants (7 Females; 7 Males) in a randomized crossover trial. The methodology discriminated between the urinary responses of control, and bran and aleurone, but not between the two fractions. Compared to control, consumption of aleurone or bran led to significantly and substantially higher urinary concentrations of lactate, alanine, N-acetylaspartate acid and N-acetylaspartylglutamate and significantly and substantially lower urinary betaine concentrations at one and two hours postprandially. There were sex related differences in urinary metabolite profiles with generally higher hippurate and citrate and lower betaine in females compared to males. Overall, this postprandial study suggests that acute consumption of bran or aleurone is associated with a number of physiological effects that may impact on energy metabolism and which are consistent with longer term human and animal metabolomic studies that used whole-grain wheat diets or wheat fractions. |
format | Online Article Text |
id | pubmed-4772058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-47720582016-03-08 Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women Garg, Ramandeep Brennan, Lorraine Price, Ruth K. Wallace, Julie M. W. Strain, J. J. Gibney, Mike J. Shewry, Peter R. Ward, Jane L. Garg, Lalit Welch, Robert W. Nutrients Article Wheat bran, and especially wheat aleurone fraction, are concentrated sources of a wide range of components which may contribute to the health benefits associated with higher consumption of whole-grain foods. This study used NMR metabolomics to evaluate urine samples from baseline at one and two hours postprandially, following the consumption of minimally processed bran, aleurone or control by 14 participants (7 Females; 7 Males) in a randomized crossover trial. The methodology discriminated between the urinary responses of control, and bran and aleurone, but not between the two fractions. Compared to control, consumption of aleurone or bran led to significantly and substantially higher urinary concentrations of lactate, alanine, N-acetylaspartate acid and N-acetylaspartylglutamate and significantly and substantially lower urinary betaine concentrations at one and two hours postprandially. There were sex related differences in urinary metabolite profiles with generally higher hippurate and citrate and lower betaine in females compared to males. Overall, this postprandial study suggests that acute consumption of bran or aleurone is associated with a number of physiological effects that may impact on energy metabolism and which are consistent with longer term human and animal metabolomic studies that used whole-grain wheat diets or wheat fractions. MDPI 2016-02-17 /pmc/articles/PMC4772058/ /pubmed/26901221 http://dx.doi.org/10.3390/nu8020096 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Garg, Ramandeep Brennan, Lorraine Price, Ruth K. Wallace, Julie M. W. Strain, J. J. Gibney, Mike J. Shewry, Peter R. Ward, Jane L. Garg, Lalit Welch, Robert W. Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women |
title | Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women |
title_full | Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women |
title_fullStr | Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women |
title_full_unstemmed | Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women |
title_short | Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women |
title_sort | using nmr-based metabolomics to evaluate postprandial urinary responses following consumption of minimally processed wheat bran or wheat aleurone by men and women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772058/ https://www.ncbi.nlm.nih.gov/pubmed/26901221 http://dx.doi.org/10.3390/nu8020096 |
work_keys_str_mv | AT gargramandeep usingnmrbasedmetabolomicstoevaluatepostprandialurinaryresponsesfollowingconsumptionofminimallyprocessedwheatbranorwheataleuronebymenandwomen AT brennanlorraine usingnmrbasedmetabolomicstoevaluatepostprandialurinaryresponsesfollowingconsumptionofminimallyprocessedwheatbranorwheataleuronebymenandwomen AT priceruthk usingnmrbasedmetabolomicstoevaluatepostprandialurinaryresponsesfollowingconsumptionofminimallyprocessedwheatbranorwheataleuronebymenandwomen AT wallacejuliemw usingnmrbasedmetabolomicstoevaluatepostprandialurinaryresponsesfollowingconsumptionofminimallyprocessedwheatbranorwheataleuronebymenandwomen AT strainjj usingnmrbasedmetabolomicstoevaluatepostprandialurinaryresponsesfollowingconsumptionofminimallyprocessedwheatbranorwheataleuronebymenandwomen AT gibneymikej usingnmrbasedmetabolomicstoevaluatepostprandialurinaryresponsesfollowingconsumptionofminimallyprocessedwheatbranorwheataleuronebymenandwomen AT shewrypeterr usingnmrbasedmetabolomicstoevaluatepostprandialurinaryresponsesfollowingconsumptionofminimallyprocessedwheatbranorwheataleuronebymenandwomen AT wardjanel usingnmrbasedmetabolomicstoevaluatepostprandialurinaryresponsesfollowingconsumptionofminimallyprocessedwheatbranorwheataleuronebymenandwomen AT garglalit usingnmrbasedmetabolomicstoevaluatepostprandialurinaryresponsesfollowingconsumptionofminimallyprocessedwheatbranorwheataleuronebymenandwomen AT welchrobertw usingnmrbasedmetabolomicstoevaluatepostprandialurinaryresponsesfollowingconsumptionofminimallyprocessedwheatbranorwheataleuronebymenandwomen |