Cargando…
Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B
A few studies showed that long-term methotrexate (MTX) use exacerbates liver fibrosis and even leads to liver cirrhosis in rheumatoid arthritis (RA) patients. We therefore conducted a population-based cohort study to investigate the impact of long-term MTX use on the risk of chronic hepatitis B (CHB...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772158/ https://www.ncbi.nlm.nih.gov/pubmed/26928373 http://dx.doi.org/10.1038/srep22387 |
_version_ | 1782418512542695424 |
---|---|
author | Tang, Kuo-Tung Hung, Wei-Ting Chen, Yi-Hsing Lin, Ching-Heng Chen, Der-Yuan |
author_facet | Tang, Kuo-Tung Hung, Wei-Ting Chen, Yi-Hsing Lin, Ching-Heng Chen, Der-Yuan |
author_sort | Tang, Kuo-Tung |
collection | PubMed |
description | A few studies showed that long-term methotrexate (MTX) use exacerbates liver fibrosis and even leads to liver cirrhosis in rheumatoid arthritis (RA) patients. We therefore conducted a population-based cohort study to investigate the impact of long-term MTX use on the risk of chronic hepatitis B (CHB)-related cirrhosis among RA patients. We analyzed data from the National Health Insurance Research Database in Taiwan and identified 631 incident cases of RA among CHB patients (358 MTX users and 273 MTX non-users) from January 1, 1998 to December 31, 2007. After a median follow-up of more than 6 years since the diagnosis of CHB, a total of 41 (6.5%) patients developed liver cirrhosis. We did not find an increased risk of liver cirrhosis among CHB patients with long-term MTX use for RA. Furthermore, there was no occurrence of liver cirrhosis among 56 MTX users with a cumulative dose ≧3 grams after 97 months’ treatment. In conclusion, our data showed that long-term MTX use is not associated with an increased risk for liver cirrhosis among RA patients with CHB. However, interpretation of the results should be cautious due to potential bias in the cohort. |
format | Online Article Text |
id | pubmed-4772158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47721582016-03-07 Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B Tang, Kuo-Tung Hung, Wei-Ting Chen, Yi-Hsing Lin, Ching-Heng Chen, Der-Yuan Sci Rep Article A few studies showed that long-term methotrexate (MTX) use exacerbates liver fibrosis and even leads to liver cirrhosis in rheumatoid arthritis (RA) patients. We therefore conducted a population-based cohort study to investigate the impact of long-term MTX use on the risk of chronic hepatitis B (CHB)-related cirrhosis among RA patients. We analyzed data from the National Health Insurance Research Database in Taiwan and identified 631 incident cases of RA among CHB patients (358 MTX users and 273 MTX non-users) from January 1, 1998 to December 31, 2007. After a median follow-up of more than 6 years since the diagnosis of CHB, a total of 41 (6.5%) patients developed liver cirrhosis. We did not find an increased risk of liver cirrhosis among CHB patients with long-term MTX use for RA. Furthermore, there was no occurrence of liver cirrhosis among 56 MTX users with a cumulative dose ≧3 grams after 97 months’ treatment. In conclusion, our data showed that long-term MTX use is not associated with an increased risk for liver cirrhosis among RA patients with CHB. However, interpretation of the results should be cautious due to potential bias in the cohort. Nature Publishing Group 2016-03-01 /pmc/articles/PMC4772158/ /pubmed/26928373 http://dx.doi.org/10.1038/srep22387 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Tang, Kuo-Tung Hung, Wei-Ting Chen, Yi-Hsing Lin, Ching-Heng Chen, Der-Yuan Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B |
title | Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B |
title_full | Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B |
title_fullStr | Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B |
title_full_unstemmed | Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B |
title_short | Methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis B |
title_sort | methotrexate is not associated with increased liver cirrhosis in a population-based cohort of rheumatoid arthritis patients with chronic hepatitis b |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772158/ https://www.ncbi.nlm.nih.gov/pubmed/26928373 http://dx.doi.org/10.1038/srep22387 |
work_keys_str_mv | AT tangkuotung methotrexateisnotassociatedwithincreasedlivercirrhosisinapopulationbasedcohortofrheumatoidarthritispatientswithchronichepatitisb AT hungweiting methotrexateisnotassociatedwithincreasedlivercirrhosisinapopulationbasedcohortofrheumatoidarthritispatientswithchronichepatitisb AT chenyihsing methotrexateisnotassociatedwithincreasedlivercirrhosisinapopulationbasedcohortofrheumatoidarthritispatientswithchronichepatitisb AT linchingheng methotrexateisnotassociatedwithincreasedlivercirrhosisinapopulationbasedcohortofrheumatoidarthritispatientswithchronichepatitisb AT chenderyuan methotrexateisnotassociatedwithincreasedlivercirrhosisinapopulationbasedcohortofrheumatoidarthritispatientswithchronichepatitisb |