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The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men

Prostate cancer (PCa) is a multifactorial disease involving complex genetic and environmental factors interactions. Gene-gene and gene-environment interactions associated with PCa in Chinese men are less studied. We explored the association between 36 SNPs and PCa in 574 subjects from northern China...

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Autores principales: Liu, Ming, Shi, Xiaohong, Yang, Fan, Wang, Jianye, Xu, Yong, Wei, Dong, Yang, Kuo, Zhang, Yaoguang, Wang, Xin, Liang, Siying, Chen, Xin, Sun, Liang, Zhu, Xiaoquan, Zhao, Chengxiao, Zhu, Ling, Tang, Lei, Zheng, Chenguang, Yang, Ze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772182/
https://www.ncbi.nlm.nih.gov/pubmed/26828504
http://dx.doi.org/10.3390/ijerph13020162
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author Liu, Ming
Shi, Xiaohong
Yang, Fan
Wang, Jianye
Xu, Yong
Wei, Dong
Yang, Kuo
Zhang, Yaoguang
Wang, Xin
Liang, Siying
Chen, Xin
Sun, Liang
Zhu, Xiaoquan
Zhao, Chengxiao
Zhu, Ling
Tang, Lei
Zheng, Chenguang
Yang, Ze
author_facet Liu, Ming
Shi, Xiaohong
Yang, Fan
Wang, Jianye
Xu, Yong
Wei, Dong
Yang, Kuo
Zhang, Yaoguang
Wang, Xin
Liang, Siying
Chen, Xin
Sun, Liang
Zhu, Xiaoquan
Zhao, Chengxiao
Zhu, Ling
Tang, Lei
Zheng, Chenguang
Yang, Ze
author_sort Liu, Ming
collection PubMed
description Prostate cancer (PCa) is a multifactorial disease involving complex genetic and environmental factors interactions. Gene-gene and gene-environment interactions associated with PCa in Chinese men are less studied. We explored the association between 36 SNPs and PCa in 574 subjects from northern China. Body mass index (BMI), smoking, and alcohol consumption were determined through self-administered questionnaires in 134 PCa patients. Then gene-gene and gene-environment interactions among the PCa-associated SNPs were analyzed using the generalized multifactor dimensionality reduction (GMDR) and logistic regression methods. Allelic and genotypic association analyses showed that six variants were associated with PCa and the cumulative effect suggested men who carried any combination of 1, 2, or ≥3 risk genotypes had a gradually increased PCa risk (odds ratios (ORs) = 1.79–4.41). GMDR analysis identified the best gene-gene interaction model with scores of 10 for both the cross-validation consistency and sign tests. For gene-environment interactions, rs6983561 CC and rs16901966 GG in individuals with a BMI ≥ 28 had ORs of 7.66 (p = 0.032) and 5.33 (p = 0.046), respectively. rs7679673 CC + CA and rs12653946 TT in individuals that smoked had ORs of 2.77 (p = 0.007) and 3.11 (p = 0.024), respectively. rs7679673 CC in individuals that consumed alcohol had an OR of 4.37 (p = 0.041). These results suggest that polymorphisms, either individually or by interacting with other genes or environmental factors, contribute to an increased risk of PCa.
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spelling pubmed-47721822016-03-08 The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men Liu, Ming Shi, Xiaohong Yang, Fan Wang, Jianye Xu, Yong Wei, Dong Yang, Kuo Zhang, Yaoguang Wang, Xin Liang, Siying Chen, Xin Sun, Liang Zhu, Xiaoquan Zhao, Chengxiao Zhu, Ling Tang, Lei Zheng, Chenguang Yang, Ze Int J Environ Res Public Health Article Prostate cancer (PCa) is a multifactorial disease involving complex genetic and environmental factors interactions. Gene-gene and gene-environment interactions associated with PCa in Chinese men are less studied. We explored the association between 36 SNPs and PCa in 574 subjects from northern China. Body mass index (BMI), smoking, and alcohol consumption were determined through self-administered questionnaires in 134 PCa patients. Then gene-gene and gene-environment interactions among the PCa-associated SNPs were analyzed using the generalized multifactor dimensionality reduction (GMDR) and logistic regression methods. Allelic and genotypic association analyses showed that six variants were associated with PCa and the cumulative effect suggested men who carried any combination of 1, 2, or ≥3 risk genotypes had a gradually increased PCa risk (odds ratios (ORs) = 1.79–4.41). GMDR analysis identified the best gene-gene interaction model with scores of 10 for both the cross-validation consistency and sign tests. For gene-environment interactions, rs6983561 CC and rs16901966 GG in individuals with a BMI ≥ 28 had ORs of 7.66 (p = 0.032) and 5.33 (p = 0.046), respectively. rs7679673 CC + CA and rs12653946 TT in individuals that smoked had ORs of 2.77 (p = 0.007) and 3.11 (p = 0.024), respectively. rs7679673 CC in individuals that consumed alcohol had an OR of 4.37 (p = 0.041). These results suggest that polymorphisms, either individually or by interacting with other genes or environmental factors, contribute to an increased risk of PCa. MDPI 2016-01-27 2016-02 /pmc/articles/PMC4772182/ /pubmed/26828504 http://dx.doi.org/10.3390/ijerph13020162 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Ming
Shi, Xiaohong
Yang, Fan
Wang, Jianye
Xu, Yong
Wei, Dong
Yang, Kuo
Zhang, Yaoguang
Wang, Xin
Liang, Siying
Chen, Xin
Sun, Liang
Zhu, Xiaoquan
Zhao, Chengxiao
Zhu, Ling
Tang, Lei
Zheng, Chenguang
Yang, Ze
The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men
title The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men
title_full The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men
title_fullStr The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men
title_full_unstemmed The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men
title_short The Cumulative Effect of Gene-Gene and Gene-Environment Interactions on the Risk of Prostate Cancer in Chinese Men
title_sort cumulative effect of gene-gene and gene-environment interactions on the risk of prostate cancer in chinese men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772182/
https://www.ncbi.nlm.nih.gov/pubmed/26828504
http://dx.doi.org/10.3390/ijerph13020162
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