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Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China

Elevated LDL-C/HDL-C ratio has been shown to be a marker of lipid metabolism as well as a good predictor of coronary artery disease (CAD). Thus, the aim of this study was to investigate whether the LDL-C/HDL-C ratio is useful for detecting cardiovascular disease (CVD) risk factors in general healthy...

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Autores principales: Chen, Qing-Jie, Lai, Hong-Mei, Chen, Bang-Dang, Li, Xiao-Mei, Zhai, Hui, He, Chun-Hui, Pan, Shuo, Luo, Jun-Yi, Gao, Jing, Liu, Fen, Ma, Yi-Tong, Yang, Yi-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772255/
https://www.ncbi.nlm.nih.gov/pubmed/26907312
http://dx.doi.org/10.3390/ijerph13020235
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author Chen, Qing-Jie
Lai, Hong-Mei
Chen, Bang-Dang
Li, Xiao-Mei
Zhai, Hui
He, Chun-Hui
Pan, Shuo
Luo, Jun-Yi
Gao, Jing
Liu, Fen
Ma, Yi-Tong
Yang, Yi-Ning
author_facet Chen, Qing-Jie
Lai, Hong-Mei
Chen, Bang-Dang
Li, Xiao-Mei
Zhai, Hui
He, Chun-Hui
Pan, Shuo
Luo, Jun-Yi
Gao, Jing
Liu, Fen
Ma, Yi-Tong
Yang, Yi-Ning
author_sort Chen, Qing-Jie
collection PubMed
description Elevated LDL-C/HDL-C ratio has been shown to be a marker of lipid metabolism as well as a good predictor of coronary artery disease (CAD). Thus, the aim of this study was to investigate whether the LDL-C/HDL-C ratio is useful for detecting cardiovascular disease (CVD) risk factors in general healthy Uygur adults in Xinjiang. A total of 4047 Uygur subjects aged ≥35 years were selected from the Cardiovascular Risk Survey (CRS) study which was carried out from October 2007 to March 2010. Anthropometric data, blood pressure, lipid profile and fasting glucose were measured in all participants. The prevalence, sensitivity, specificity and distance on the receiver operating characteristic (ROC) curve of each LDL-C/HDL-C ratio were calculated. The prevalence of high LDL-C and low HDL-C cholesterol was high and positively correlated with higher LDL-C/HDL-C ratio in the Uygur population. In both men and women, we detected a slight apparent trend of high prevalence of hypertension and hypercholesterolemia with higher LDL-C/HDL-C ratio. Our study also demonstrated that the discriminatory power of the LDL-C/HDL-C ratio for CVD risk factors was slightly stronger in men than in women. Analysis of the shortest distance in the ROC curves for hypertension, dyslipidemia, diabetes, or ≥two of these risk factors suggested a LDL-C/HDL-C ratio cutoff of 2.5 for both men and women. The results of this study showed that a LDL-C/HDL-C ratio cut-off of 2.5 might be used as the predictive marker to detect CVD risk factors among Uygur adults in Xinjiang.
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spelling pubmed-47722552016-03-08 Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China Chen, Qing-Jie Lai, Hong-Mei Chen, Bang-Dang Li, Xiao-Mei Zhai, Hui He, Chun-Hui Pan, Shuo Luo, Jun-Yi Gao, Jing Liu, Fen Ma, Yi-Tong Yang, Yi-Ning Int J Environ Res Public Health Article Elevated LDL-C/HDL-C ratio has been shown to be a marker of lipid metabolism as well as a good predictor of coronary artery disease (CAD). Thus, the aim of this study was to investigate whether the LDL-C/HDL-C ratio is useful for detecting cardiovascular disease (CVD) risk factors in general healthy Uygur adults in Xinjiang. A total of 4047 Uygur subjects aged ≥35 years were selected from the Cardiovascular Risk Survey (CRS) study which was carried out from October 2007 to March 2010. Anthropometric data, blood pressure, lipid profile and fasting glucose were measured in all participants. The prevalence, sensitivity, specificity and distance on the receiver operating characteristic (ROC) curve of each LDL-C/HDL-C ratio were calculated. The prevalence of high LDL-C and low HDL-C cholesterol was high and positively correlated with higher LDL-C/HDL-C ratio in the Uygur population. In both men and women, we detected a slight apparent trend of high prevalence of hypertension and hypercholesterolemia with higher LDL-C/HDL-C ratio. Our study also demonstrated that the discriminatory power of the LDL-C/HDL-C ratio for CVD risk factors was slightly stronger in men than in women. Analysis of the shortest distance in the ROC curves for hypertension, dyslipidemia, diabetes, or ≥two of these risk factors suggested a LDL-C/HDL-C ratio cutoff of 2.5 for both men and women. The results of this study showed that a LDL-C/HDL-C ratio cut-off of 2.5 might be used as the predictive marker to detect CVD risk factors among Uygur adults in Xinjiang. MDPI 2016-02-19 2016-02 /pmc/articles/PMC4772255/ /pubmed/26907312 http://dx.doi.org/10.3390/ijerph13020235 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Qing-Jie
Lai, Hong-Mei
Chen, Bang-Dang
Li, Xiao-Mei
Zhai, Hui
He, Chun-Hui
Pan, Shuo
Luo, Jun-Yi
Gao, Jing
Liu, Fen
Ma, Yi-Tong
Yang, Yi-Ning
Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China
title Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China
title_full Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China
title_fullStr Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China
title_full_unstemmed Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China
title_short Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China
title_sort appropriate ldl-c-to-hdl-c ratio cutoffs for categorization of cardiovascular disease risk factors among uygur adults in xinjiang, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772255/
https://www.ncbi.nlm.nih.gov/pubmed/26907312
http://dx.doi.org/10.3390/ijerph13020235
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