Cargando…

Pharmacokinetics and Concentration-Effect Relationship of Oral LSD in Humans

BACKGROUND: The pharmacokinetics of oral lysergic acid diethylamide are unknown despite its common recreational use and renewed interest in its use in psychiatric research and practice. METHODS: We characterized the pharmacokinetic profile, pharmacokinetic-pharmacodynamic relationship, and urine rec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dolder, Patrick C., Schmid, Yasmin, Haschke, Manuel, Rentsch, Katharina M., Liechti, Matthias E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772267/ https://www.ncbi.nlm.nih.gov/pubmed/26108222 http://dx.doi.org/10.1093/ijnp/pyv072

Ejemplares similares

Alterations of consciousness and mystical-type experiences after acute LSD in humans
por: Liechti, Matthias E., et al.
Publicado: (2016)

Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis
por: Vizeli, Patrick, et al.
Publicado: (2021)

LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality
por: Dolder, Patrick C, et al.
Publicado: (2016)

Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects
por: Dolder, Patrick C., et al.
Publicado: (2017)

Long-lasting subjective effects of LSD in normal subjects
por: Schmid, Yasmin, et al.
Publicado: (2017)

Altered network hub connectivity after acute LSD administration
por: Müller, Felix, et al.
Publicado: (2018)

Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects
por: Mueller, F, et al.
Publicado: (2017)

Presentations due to acute toxicity of psychoactive substances in an urban emergency department in Switzerland: a case series
por: Liakoni, Evangelia, et al.
Publicado: (2016)

Modern Clinical Research on LSD
por: Liechti, Matthias E
Publicado: (2017)

Flashback phenomena after administration of LSD and psilocybin in controlled studies with healthy participants
por: Müller, Felix, et al.
Publicado: (2022)

Increased thalamic resting‐state connectivity as a core driver of LSD‐induced hallucinations
por: Müller, F., et al.
Publicado: (2017)

Direct comparison of the acute subjective, emotional, autonomic, and endocrine effects of MDMA, methylphenidate, and modafinil in healthy subjects
por: Dolder, Patrick C., et al.
Publicado: (2017)

A Single Dose of LSD Does Not Alter Gene Expression of the Serotonin 2A Receptor Gene (HTR2A) or Early Growth Response Genes (EGR1-3) in Healthy Subjects
por: Dolder, Patrick C., et al.
Publicado: (2017)

Comparative Effects of Methylphenidate, Modafinil, and MDMA on Response Inhibition Neural Networks in Healthy Subjects
por: Schmidt, André, et al.
Publicado: (2017)

Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects
por: Dolder, Patrick C., et al.
Publicado: (2017)

Safety pharmacology of acute LSD administration in healthy subjects
por: Holze, Friederike, et al.
Publicado: (2021)

Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers
por: Hutten, Nadia R. P. W., et al.
Publicado: (2020)

Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing
por: Schmidt, André, et al.
Publicado: (2017)

Distinct acute effects of LSD, MDMA, and d-amphetamine in healthy subjects
por: Holze, Friederike, et al.
Publicado: (2019)

CYP2D6 function moderates the pharmacokinetics and pharmacodynamics of 3,4-methylene-dioxymethamphetamine in a controlled study in healthy individuals
por: Schmid, Yasmin, et al.
Publicado: (2016)

Role of the 5-HT(2A) Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin
por: Holze, Friederike, et al.
Publicado: (2021)

The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity
por: Bedford, Peter, et al.
Publicado: (2023)

Dose-response relationships of LSD-induced subjective experiences in humans
por: Hirschfeld, Tim, et al.
Publicado: (2023)

Impact of Cytochrome P450 2D6 Function on the Chiral Blood Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine (MDMA) and Its Phase I and II Metabolites in Humans
por: Steuer, Andrea E., et al.
Publicado: (2016)

Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide Microdoses in Healthy Participants
por: Holze, Friederike, et al.
Publicado: (2020)

Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2
por: Niwa, Hideaki, et al.
Publicado: (2022)

Targeting oral cancer epigenome via LSD1
por: Bais, Manish V.
Publicado: (2017)

Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants
por: Straumann, Isabelle, et al.
Publicado: (2023)

Multifaceted empathy of healthy volunteers after single doses of MDMA: A pooled sample of placebo-controlled studies
por: Kuypers, Kim PC, et al.
Publicado: (2017)

Treatment of a Complex Personality Disorder Using Repeated Doses of LSD—A Case Report on Significant Improvements in the Absence of Acute Drug Effects
por: Müller, Felix, et al.
Publicado: (2020)

MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens
por: Müller, Felix, et al.
Publicado: (2020)

The Role of LSD1 and LSD2 in Cancers of the Gastrointestinal System: An Update
por: Malagraba, Gianluca, et al.
Publicado: (2022)

Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans
por: Kanen, Jonathan W., et al.
Publicado: (2023)

Ketanserin Reverses the Acute Response to LSD in a Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Participants
por: Becker, Anna M, et al.
Publicado: (2022)

A Study of the Relationship between Serum Bile Acids and Propranolol Pharmacokinetics and Pharmacodynamics in Patients with Liver Cirrhosis and in Healthy Controls
por: Taegtmeyer, Anne B., et al.
Publicado: (2014)

Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis
por: Alsaqer, Saqer F., et al.
Publicado: (2017)

Effective connectivity changes in LSD-induced altered states of consciousness in humans
por: Preller, Katrin H., et al.
Publicado: (2019)

Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers
por: Family, Neiloufar, et al.
Publicado: (2019)

LSD alters dynamic integration and segregation in the human brain
por: Luppi, Andrea I., et al.
Publicado: (2021)

LSD: individuo y sociedad
Publicado: (1970)

Cannot write session to /tmp/vufind_sessions/sess_nnq9fkkula2ftfvpgkmr00jnu7