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Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma
BACKGROUND: The impacts of weight loss on prognosis in nasopharyngeal carcinoma (NPC) remain unclear. The present study was therefore undertaken to investigate the association between critical weight loss and long-term survival in NPC patients. METHODS: The eligible 2399 NPC patients were reviewed....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772285/ https://www.ncbi.nlm.nih.gov/pubmed/26926144 http://dx.doi.org/10.1186/s12885-016-2214-4 |
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author | Zeng, Qi Shen, Lu-Jun Guo, Xiang Guo, Xin-Ming Qian, Chao-Nan Wu, Pei-Hong |
author_facet | Zeng, Qi Shen, Lu-Jun Guo, Xiang Guo, Xin-Ming Qian, Chao-Nan Wu, Pei-Hong |
author_sort | Zeng, Qi |
collection | PubMed |
description | BACKGROUND: The impacts of weight loss on prognosis in nasopharyngeal carcinoma (NPC) remain unclear. The present study was therefore undertaken to investigate the association between critical weight loss and long-term survival in NPC patients. METHODS: The eligible 2399 NPC patients were reviewed. Weight change was categorized into critical weight loss (CWL) and non-critical weight loss (Non-CWL). The associations of CWL with long-term survival were analyzed by Cox regression in the entire patient and two subsets. Propensity score matching was performed to reduce the effects of confounding factors. RESULTS: CWL was defined as body weight loss of ≥4.6 %. Compared with patients without CWL, patients with CWL had significantly lower 5-year OS (72.4 vs. 79.3 %, P < 0.001), FFS (71.1 vs. 78.4 %, P <0.001), and LR-FFS (78.1 vs. 84.8 %, P <0.001), respectively. After adjustment for potential confounders, CWL remained an independence prognostic factor for OS (HR = 1.352; 95 % CI 1.160–1.576; P < 0.001), FFS (HR = 3.275; 95 % CI 1.101–9.740; P = 0.033), and LR-FFS (HR = 6.620; 95 % CI 2.990–14.658; P < 0.001), respectively. Furthermore, subgroup analysis in the cohort of patients received concurrent chemoradiotherapy or radiotherapy alone confirmed the results in the entire patient even after the propensity-score matching. In IMRT cohort, CWL was also significantly associated with a lower OS (P = 0.04) and FFS (P = 0.04). CONCLUSIONS: CWL has a significant and independent impact on long-term survival in nasopharyngeal carcinoma patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-016-2214-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4772285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47722852016-03-02 Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma Zeng, Qi Shen, Lu-Jun Guo, Xiang Guo, Xin-Ming Qian, Chao-Nan Wu, Pei-Hong BMC Cancer Research Article BACKGROUND: The impacts of weight loss on prognosis in nasopharyngeal carcinoma (NPC) remain unclear. The present study was therefore undertaken to investigate the association between critical weight loss and long-term survival in NPC patients. METHODS: The eligible 2399 NPC patients were reviewed. Weight change was categorized into critical weight loss (CWL) and non-critical weight loss (Non-CWL). The associations of CWL with long-term survival were analyzed by Cox regression in the entire patient and two subsets. Propensity score matching was performed to reduce the effects of confounding factors. RESULTS: CWL was defined as body weight loss of ≥4.6 %. Compared with patients without CWL, patients with CWL had significantly lower 5-year OS (72.4 vs. 79.3 %, P < 0.001), FFS (71.1 vs. 78.4 %, P <0.001), and LR-FFS (78.1 vs. 84.8 %, P <0.001), respectively. After adjustment for potential confounders, CWL remained an independence prognostic factor for OS (HR = 1.352; 95 % CI 1.160–1.576; P < 0.001), FFS (HR = 3.275; 95 % CI 1.101–9.740; P = 0.033), and LR-FFS (HR = 6.620; 95 % CI 2.990–14.658; P < 0.001), respectively. Furthermore, subgroup analysis in the cohort of patients received concurrent chemoradiotherapy or radiotherapy alone confirmed the results in the entire patient even after the propensity-score matching. In IMRT cohort, CWL was also significantly associated with a lower OS (P = 0.04) and FFS (P = 0.04). CONCLUSIONS: CWL has a significant and independent impact on long-term survival in nasopharyngeal carcinoma patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-016-2214-4) contains supplementary material, which is available to authorized users. BioMed Central 2016-02-29 /pmc/articles/PMC4772285/ /pubmed/26926144 http://dx.doi.org/10.1186/s12885-016-2214-4 Text en © Zeng et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zeng, Qi Shen, Lu-Jun Guo, Xiang Guo, Xin-Ming Qian, Chao-Nan Wu, Pei-Hong Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma |
title | Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma |
title_full | Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma |
title_fullStr | Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma |
title_full_unstemmed | Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma |
title_short | Critical weight loss predicts poor prognosis in nasopharyngeal carcinoma |
title_sort | critical weight loss predicts poor prognosis in nasopharyngeal carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772285/ https://www.ncbi.nlm.nih.gov/pubmed/26926144 http://dx.doi.org/10.1186/s12885-016-2214-4 |
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