Cargando…

Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1β axis in mice

The mitochondrial sirtuin 3 (SIRT3) is involved in suppressing the onset of multiple pathologies, including cardiovascular disease, fatty liver, age-related hearing loss, and breast cancer. But a physiological role of SIRT3 in bone metabolism is not known. Here we show that SIRT3 is a key regulatory...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huh, Jeong-Eun, Shin, Ji Hye, Jang, Eun Sun, Park, So Jeong, Park, Doo Ri, Ko, Ryeojin, Seo, Dong-Hyun, Kim, Han-Sung, Lee, Seoung Hoon, Choi, Yongwon, Kim, Hyun Seok, Lee, Soo Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772385/ https://www.ncbi.nlm.nih.gov/pubmed/26928655 http://dx.doi.org/10.1038/srep22511

Ejemplares similares

Sirt6 cooperates with Blimp1 to positively regulate osteoclast differentiation
por: Park, So Jeong, et al.
Publicado: (2016)

D-allulose ameliorates adiposity through the AMPK-SIRT1-PGC-1α pathway in HFD-induced SD rats
por: Lee, Geum-Hwa, et al.
Publicado: (2021)

Glycogen Synthase Kinase 3β Promotes Osteogenic Differentiation of Murine Adipose-Derived Stromal Cells
por: Huh, Jeong-Eun, et al.
Publicado: (2013)

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
por: Palacios, Orsolya M., et al.
Publicado: (2009)

Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production
por: Ko, Ryeojin, et al.
Publicado: (2015)

Melatonin Reduces Aggravation of Renal Ischemia–Reperfusion Injury in Obese Rats by Maintaining Mitochondrial Homeostasis and Integrity through AMPK/PGC-1α/SIRT3/SOD2 Activation
por: Kobroob, Anongporn, et al.
Publicado: (2023)

Omega-3 Fatty Acids Upregulate SIRT1/3, Activate PGC-1α via Deacetylation, and Induce Nrf1 Production in 5/6 Nephrectomy Rat Model
por: Son, Sung Hyun, et al.
Publicado: (2021)

Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PGC-1α-SIRT3 Pathway in the Human Erectile Tissue
por: Pereira, Andressa S., et al.
Publicado: (2020)

SIRT1 Promotes Host Protective Immunity against Toxoplasma gondii by Controlling the FoxO-Autophagy Axis via the AMPK and PI3K/AKT Signalling Pathways
por: Lee, Jina, et al.
Publicado: (2022)

The effect of SIRT1 protein knock down on PGC-1α acetylation during skeletal muscle contraction
por: Park, Dae Ryoung, et al.
Publicado: (2014)

Chitooligosaccharide Induces Mitochondrial Biogenesis and Increases Exercise Endurance through the Activation of Sirt1 and AMPK in Rats
por: Jeong, Hyun Woo, et al.
Publicado: (2012)

Black Wheat Extracts (Arriheuk) Regulate Adipogenesis and Lipolysis via Adenosine Monophosphate (AMP) Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Signaling Pathways
por: Yoon, Young, et al.
Publicado: (2023)

Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway
por: GUAN, YUE, et al.
Publicado: (2016)

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK
por: Park, Sung-Jun, et al.
Publicado: (2017)

Sirtuin 3 (SIRT3) Pathways in Age-Related Cardiovascular and Neurodegenerative Diseases
por: Silaghi, Ciprian N., et al.
Publicado: (2021)

Salvianolic Acid A Protects the Peripheral Nerve Function in Diabetic Rats through Regulation of the AMPK-PGC1α-Sirt3 Axis
por: Yu, Xiaoyan, et al.
Publicado: (2012)

Bioactive Peptides and Exercise Modulate the AMPK/SIRT1/PGC-1α/FOXO3 Pathway as a Therapeutic Approach for Hypertensive Rats
por: Ho, Jou-Hsuan, et al.
Publicado: (2022)

Distinct role of Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) in inhibiting cargo-loading and release of extracellular vesicles
por: Lee, Byung Rho, et al.
Publicado: (2019)

Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway
por: Yin, Junxiang, et al.
Publicado: (2019)

PARP-1 and SIRT-1 are Interacted in Diabetic Nephropathy by Activating AMPK/PGC-1α Signaling Pathway
por: Zhu, Hengmei, et al.
Publicado: (2021)

Multiple Roles of Sirtuin 6 in Adipose Tissue Inflammation
por: Bae, Eun Ju, et al.
Publicado: (2023)

Expression of SIRT1 and SIRT3 varies according to age in mice
por: Kwon, Youngho, et al.
Publicado: (2015)

Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions
por: Han, Yoon-Mi, et al.
Publicado: (2020)

MCU-Dependent mROS Generation Regulates Cell Metabolism and Cell Death Modulated by the AMPK/PGC-1α/SIRT3 Signaling Pathway
por: Wang, Yuxin, et al.
Publicado: (2021)

Inhibition of the Peroxisome Proliferator-Activated Receptor gamma Coactivator 1-alpha (PGC-1α)/Sirtuin 3 (SIRT3) Pathway Aggravates Oxidative Stress After Experimental Subarachnoid Hemorrhage
por: Zhang, Ke, et al.
Publicado: (2020)

Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses
por: Heinonen, Tytti, et al.
Publicado: (2019)

Sirtuin-3 (SIRT3), a Novel Potential Therapeutic Target for Oral Cancer
por: Alhazzazi, Turki Y, et al.
Publicado: (2011)

Sirtuins and SIRT6 in Carcinogenesis and in Diet
por: de Céu Teixeira, Maria, et al.
Publicado: (2019)

P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice
por: Dusabimana, Theodomir, et al.
Publicado: (2021)

Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway
por: Li, Jiye, et al.
Publicado: (2020)

Myostatin Knockout Affects Mitochondrial Function by Inhibiting the AMPK/SIRT1/PGC1α Pathway in Skeletal Muscle
por: Gu, Mingjuan, et al.
Publicado: (2022)

Diallyl trisulfide alleviates chemotherapy sensitivity of ovarian cancer via the AMPK/SIRT1/PGC1α pathway
por: Wang, Zhaojun, et al.
Publicado: (2022)

Empagliflozin attenuates doxorubicin-induced cardiotoxicity by activating AMPK/SIRT-1/PGC-1α-mediated mitochondrial biogenesis
por: Chen, Meicong
Publicado: (2023)

AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesis
por: Chaube, B, et al.
Publicado: (2015)

Depression of Mitochondrial Function in the Rat Skeletal Muscle Model of Myofascial Pain Syndrome Is Through Down-Regulation of the AMPK-PGC-1α-SIRT3 Axis
por: Ye, Le, et al.
Publicado: (2020)

Icariside II, a Naturally Occurring SIRT3 Agonist, Protects against Myocardial Infarction through the AMPK/PGC-1α/Apoptosis Signaling Pathway
por: Li, Yeli, et al.
Publicado: (2022)

Remote ischemic preconditioning protects against spinal cord ischemia–reperfusion injury in mice by activating NMDAR/AMPK/PGC-1α/SIRT3 signaling
por: Gu, Changjiang, et al.
Publicado: (2023)

Sirtuin (Sirt) 3 Overexpression Prevents Retinopathy in Streptozotocin-Induced Diabetic Rats
por: Mao, Xin-bang, et al.
Publicado: (2020)

Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
por: Jung, Hoe-Yune, et al.
Publicado: (2017)

Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis
por: Kim, Young Jae, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_f5uaf37jp605gat8hiiuiguo0o