Cargando…
Extensive respiratory chain defects in inhibitory interneurones in patients with mitochondrial disease
AIMS: Mitochondrial disorders are among the most frequently inherited cause of neurological disease and arise due to mutations in mitochondrial or nuclear DNA. Currently, we do not understand the specific involvement of certain brain regions or selective neuronal vulnerability in mitochondrial disea...
Autores principales: | Lax, Nichola Z., Grady, John, Laude, Alex, Chan, Felix, Hepplewhite, Philippa D., Gorman, Grainne, Whittaker, Roger G., Ng, Yi, Cunningham, Mark O., Turnbull, Doug M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772453/ https://www.ncbi.nlm.nih.gov/pubmed/25786813 http://dx.doi.org/10.1111/nan.12238 |
Ejemplares similares
-
Investigating complex I deficiency in Purkinje cells and synapses in patients with mitochondrial disease
por: Chrysostomou, Alexia, et al.
Publicado: (2015) -
Delineating selective vulnerability of inhibitory interneurons in Alpers' syndrome
por: Smith, Laura A., et al.
Publicado: (2022) -
Microangiopathy in the cerebellum of patients with mitochondrial DNA disease
por: Lax, Nichola Z., et al.
Publicado: (2012) -
Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue
por: Grünewald, Anne, et al.
Publicado: (2014) -
Mitochondrial DNA Depletion in Respiratory Chain–Deficient Parkinson Disease Neurons
por: Grünewald, Anne, et al.
Publicado: (2016)