Identification of Loci Modulating the Cardiovascular and Skeletal Phenotypes of Marfan Syndrome in Mice

Marfan syndrome (MFS) is an autosomal dominant disease of the connective tissue, affecting mostly the skeletal, ocular and cardiovascular systems, caused by mutations in the FBN1 gene. The existence of modifier genes has been postulated based on the wide clinical variability of manifestations in pat...

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Detalles Bibliográficos
Autores principales: Fernandes, Gustavo R., Massironi, Silvia M. G., Pereira, Lygia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772474/
https://www.ncbi.nlm.nih.gov/pubmed/26927851
http://dx.doi.org/10.1038/srep22426

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