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Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia
Social cognition is an important determinant of functional impairment in schizophrenia, but its relationship with the prefrontal functional abnormalities associated with the condition is still unclear. The present study aimed to explore the relationship between social cognition and prefrontal functi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772542/ https://www.ncbi.nlm.nih.gov/pubmed/26928254 http://dx.doi.org/10.1038/srep22500 |
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author | Pu, Shenghong Nakagome, Kazuyuki Yamada, Takeshi Itakura, Masashi Yamanashi, Takehiko Yamada, Sayaka Masai, Mieko Miura, Akihiko Yamauchi, Takahira Satake, Takahiro Iwata, Masaaki Nagata, Izumi Roberts, David L. Kaneko, Koichi |
author_facet | Pu, Shenghong Nakagome, Kazuyuki Yamada, Takeshi Itakura, Masashi Yamanashi, Takehiko Yamada, Sayaka Masai, Mieko Miura, Akihiko Yamauchi, Takahira Satake, Takahiro Iwata, Masaaki Nagata, Izumi Roberts, David L. Kaneko, Koichi |
author_sort | Pu, Shenghong |
collection | PubMed |
description | Social cognition is an important determinant of functional impairment in schizophrenia, but its relationship with the prefrontal functional abnormalities associated with the condition is still unclear. The present study aimed to explore the relationship between social cognition and prefrontal function in patients with schizophrenia using 52-channel near-infrared spectroscopy (NIRS). Twenty-six patients with schizophrenia and 26 age-, gender-, and intelligence quotient-matched healthy controls (HCs) participated in the study. Hemodynamic responses in the prefrontal and superior temporal cortical regions were assessed during a working memory task using NIRS. Social cognition was assessed using the Social Cognition Screening Questionnaire (SCSQ). The observed hemodynamic responses were significantly reduced in the lateral prefrontal cortex (PFC), the frontopolar cortex, and temporal regions in subjects with schizophrenia compared to HCs. Additionally, lateral PFC hemodynamic responses assessed during the working memory task demonstrated a strong positive correlation with the SCSQ theory of mind (ToM) subscale score even after controlling for working memory performance. These results suggest that ToM integrity is closely related to lateral PFC functional abnormalities found in patients with schizophrenia. In addition, this study provides evidence to suggest that NIRS could be used to identify biomarkers of social cognition function in subjects with schizophrenia. |
format | Online Article Text |
id | pubmed-4772542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47725422016-03-07 Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia Pu, Shenghong Nakagome, Kazuyuki Yamada, Takeshi Itakura, Masashi Yamanashi, Takehiko Yamada, Sayaka Masai, Mieko Miura, Akihiko Yamauchi, Takahira Satake, Takahiro Iwata, Masaaki Nagata, Izumi Roberts, David L. Kaneko, Koichi Sci Rep Article Social cognition is an important determinant of functional impairment in schizophrenia, but its relationship with the prefrontal functional abnormalities associated with the condition is still unclear. The present study aimed to explore the relationship between social cognition and prefrontal function in patients with schizophrenia using 52-channel near-infrared spectroscopy (NIRS). Twenty-six patients with schizophrenia and 26 age-, gender-, and intelligence quotient-matched healthy controls (HCs) participated in the study. Hemodynamic responses in the prefrontal and superior temporal cortical regions were assessed during a working memory task using NIRS. Social cognition was assessed using the Social Cognition Screening Questionnaire (SCSQ). The observed hemodynamic responses were significantly reduced in the lateral prefrontal cortex (PFC), the frontopolar cortex, and temporal regions in subjects with schizophrenia compared to HCs. Additionally, lateral PFC hemodynamic responses assessed during the working memory task demonstrated a strong positive correlation with the SCSQ theory of mind (ToM) subscale score even after controlling for working memory performance. These results suggest that ToM integrity is closely related to lateral PFC functional abnormalities found in patients with schizophrenia. In addition, this study provides evidence to suggest that NIRS could be used to identify biomarkers of social cognition function in subjects with schizophrenia. Nature Publishing Group 2016-03-01 /pmc/articles/PMC4772542/ /pubmed/26928254 http://dx.doi.org/10.1038/srep22500 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Pu, Shenghong Nakagome, Kazuyuki Yamada, Takeshi Itakura, Masashi Yamanashi, Takehiko Yamada, Sayaka Masai, Mieko Miura, Akihiko Yamauchi, Takahira Satake, Takahiro Iwata, Masaaki Nagata, Izumi Roberts, David L. Kaneko, Koichi Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia |
title | Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia |
title_full | Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia |
title_fullStr | Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia |
title_full_unstemmed | Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia |
title_short | Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia |
title_sort | social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772542/ https://www.ncbi.nlm.nih.gov/pubmed/26928254 http://dx.doi.org/10.1038/srep22500 |
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