Cargando…
Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation
RATIONALE: Telomerase is a nuclear regulator of telomere elongation with recent reports suggesting a role in regulation of mitochondrial reactive oxygen species. Flow-mediated dilation in patients with cardiovascular disease is dependent on the formation of reactive oxygen species. OBJECTIVE: We exa...
Autores principales: | Beyer, Andreas M., Freed, Julie K., Durand, Matthew J., Riedel, Michael, Ait-Aissa, Karima, Green, Paula, Hockenberry, Joseph C., Morgan, R. Garret, Donato, Anthony J., Peleg, Refael, Gasparri, Mario, Rokkas, Chris K., Santos, Janine H., Priel, Esther, Gutterman, David D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772813/ https://www.ncbi.nlm.nih.gov/pubmed/26699654 http://dx.doi.org/10.1161/CIRCRESAHA.115.307918 |
Ejemplares similares
-
Expression of functional alternative telomerase RNA component gene in mouse brain and in motor neurons cells protects from oxidative stress
por: Eitan, Erez, et al.
Publicado: (2016) -
Manipulation of the Sphingolipid Rheostat Influences the Mediator of Flow‐Induced Dilation in the Human Microvasculature
por: Schulz, Mary E., et al.
Publicado: (2019) -
Noncanonical Role of Telomerase in Regulation of Microvascular Redox Environment With Implications for Coronary Artery Disease
por: Ait-Aissa, K, et al.
Publicado: (2022) -
Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury
por: Ait-Aissa, Karima, et al.
Publicado: (2019) -
Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection—The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative Stress
por: Quryshi, Nabeel, et al.
Publicado: (2018)