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pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices
Devices resident in the stomach -- which are used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric retentive dosage forms for prolonged drug delivery -- typically incorporate elastic polymers to c...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772966/ https://www.ncbi.nlm.nih.gov/pubmed/26213897 http://dx.doi.org/10.1038/nmat4355 |
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author | Zhang, Shiyi Bellinger, Andrew M. Glettig, Dean L. Barman, Ross Lee, Young-Ah Lucy Zhu, Jiahua Cleveland, Cody Montgomery, Veronica A Gu, Li Nash, Landon D. Maitland, Duncan J. Langer, Robert Traverso, Giovanni |
author_facet | Zhang, Shiyi Bellinger, Andrew M. Glettig, Dean L. Barman, Ross Lee, Young-Ah Lucy Zhu, Jiahua Cleveland, Cody Montgomery, Veronica A Gu, Li Nash, Landon D. Maitland, Duncan J. Langer, Robert Traverso, Giovanni |
author_sort | Zhang, Shiyi |
collection | PubMed |
description | Devices resident in the stomach -- which are used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric retentive dosage forms for prolonged drug delivery -- typically incorporate elastic polymers to compress the devices during delivery through the esophagus and other narrow orifices in the digestive system. However, in the event of accidental device fracture or migration, the non-degradable nature of these materials risks intestinal obstruction. Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. In a large animal model, prototype devices with these materials as the key component demonstrated prolonged gastric retention and safe passage. These enteric elastomers should increase the safety profile for a wide range of gastric retentive devices. |
format | Online Article Text |
id | pubmed-4772966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-47729662016-04-01 pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices Zhang, Shiyi Bellinger, Andrew M. Glettig, Dean L. Barman, Ross Lee, Young-Ah Lucy Zhu, Jiahua Cleveland, Cody Montgomery, Veronica A Gu, Li Nash, Landon D. Maitland, Duncan J. Langer, Robert Traverso, Giovanni Nat Mater Article Devices resident in the stomach -- which are used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric retentive dosage forms for prolonged drug delivery -- typically incorporate elastic polymers to compress the devices during delivery through the esophagus and other narrow orifices in the digestive system. However, in the event of accidental device fracture or migration, the non-degradable nature of these materials risks intestinal obstruction. Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. In a large animal model, prototype devices with these materials as the key component demonstrated prolonged gastric retention and safe passage. These enteric elastomers should increase the safety profile for a wide range of gastric retentive devices. 2015-07-27 2015-10 /pmc/articles/PMC4772966/ /pubmed/26213897 http://dx.doi.org/10.1038/nmat4355 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Zhang, Shiyi Bellinger, Andrew M. Glettig, Dean L. Barman, Ross Lee, Young-Ah Lucy Zhu, Jiahua Cleveland, Cody Montgomery, Veronica A Gu, Li Nash, Landon D. Maitland, Duncan J. Langer, Robert Traverso, Giovanni pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices |
title | pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices |
title_full | pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices |
title_fullStr | pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices |
title_full_unstemmed | pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices |
title_short | pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices |
title_sort | ph-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772966/ https://www.ncbi.nlm.nih.gov/pubmed/26213897 http://dx.doi.org/10.1038/nmat4355 |
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