Dihydrofolate-Reductase Mutations in Plasmodium knowlesi Appear Unrelated to Selective Drug Pressure from Putative Human-To-Human Transmission in Sabah, Malaysia

BACKGROUND: Malaria caused by zoonotic Plasmodium knowlesi is an emerging threat in Eastern Malaysia. Despite demonstrated vector competency, it is unknown whether human-to-human (H-H) transmission is occurring naturally. We sought evidence of drug selection pressure from the antimalarial sulfadoxin...

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Detalles Bibliográficos
Autores principales: Grigg, Matthew J., Barber, Bridget E., Marfurt, Jutta, Imwong, Mallika, William, Timothy, Bird, Elspeth, Piera, Kim A., Aziz, Ammar, Boonyuen, Usa, Drakeley, Christopher J., Cox, Jonathan, White, Nicholas J., Cheng, Qin, Yeo, Tsin W., Auburn, Sarah, Anstey, Nicholas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773021/
https://www.ncbi.nlm.nih.gov/pubmed/26930493
http://dx.doi.org/10.1371/journal.pone.0149519

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