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The Transmission and Antibiotic Resistance Variation in a Multiple Drug Resistance Clade of Vibrio cholerae Circulating in Multiple Countries in Asia

Vibrio cholerae has caused massive outbreaks and even trans-continental epidemics. In 2008 and 2010, at least 3 remarkable cholera outbreaks occurred in Hainan, Anhui and Jiangsu provinces of China. To address the possible transmissions and the relationships to the 7(th) pandemic strains of those 3...

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Autores principales: Pang, Bo, Du, Pengcheng, Zhou, Zhemin, Diao, Baowei, Cui, Zhigang, Zhou, Haijian, Kan, Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773069/
https://www.ncbi.nlm.nih.gov/pubmed/26930352
http://dx.doi.org/10.1371/journal.pone.0149742
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author Pang, Bo
Du, Pengcheng
Zhou, Zhemin
Diao, Baowei
Cui, Zhigang
Zhou, Haijian
Kan, Biao
author_facet Pang, Bo
Du, Pengcheng
Zhou, Zhemin
Diao, Baowei
Cui, Zhigang
Zhou, Haijian
Kan, Biao
author_sort Pang, Bo
collection PubMed
description Vibrio cholerae has caused massive outbreaks and even trans-continental epidemics. In 2008 and 2010, at least 3 remarkable cholera outbreaks occurred in Hainan, Anhui and Jiangsu provinces of China. To address the possible transmissions and the relationships to the 7(th) pandemic strains of those 3 outbreaks, we sequenced the whole genomes of the outbreak isolates and compared with the global isolates from the 7(th) pandemic. The three outbreaks in this study were caused by a cluster of V. cholerae in clade 3.B which is parallel to the clade 3.C that was transmitted from Nepal to Haiti and caused an outbreak in 2010. Pan-genome analysis provided additional evolution information on the mobile element and acquired multiple antibiotic resistance genes. We suggested that clade 3.B should be monitored because the multiple antibiotic resistant characteristics of this clade and the ‘amplifier’ function of China in the global transmission of current Cholera pandemic. We also show that dedicated whole genome sequencing analysis provided more information than the previous techniques and should be applied in the disease surveillance networks.
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spelling pubmed-47730692016-03-07 The Transmission and Antibiotic Resistance Variation in a Multiple Drug Resistance Clade of Vibrio cholerae Circulating in Multiple Countries in Asia Pang, Bo Du, Pengcheng Zhou, Zhemin Diao, Baowei Cui, Zhigang Zhou, Haijian Kan, Biao PLoS One Research Article Vibrio cholerae has caused massive outbreaks and even trans-continental epidemics. In 2008 and 2010, at least 3 remarkable cholera outbreaks occurred in Hainan, Anhui and Jiangsu provinces of China. To address the possible transmissions and the relationships to the 7(th) pandemic strains of those 3 outbreaks, we sequenced the whole genomes of the outbreak isolates and compared with the global isolates from the 7(th) pandemic. The three outbreaks in this study were caused by a cluster of V. cholerae in clade 3.B which is parallel to the clade 3.C that was transmitted from Nepal to Haiti and caused an outbreak in 2010. Pan-genome analysis provided additional evolution information on the mobile element and acquired multiple antibiotic resistance genes. We suggested that clade 3.B should be monitored because the multiple antibiotic resistant characteristics of this clade and the ‘amplifier’ function of China in the global transmission of current Cholera pandemic. We also show that dedicated whole genome sequencing analysis provided more information than the previous techniques and should be applied in the disease surveillance networks. Public Library of Science 2016-03-01 /pmc/articles/PMC4773069/ /pubmed/26930352 http://dx.doi.org/10.1371/journal.pone.0149742 Text en © 2016 Pang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pang, Bo
Du, Pengcheng
Zhou, Zhemin
Diao, Baowei
Cui, Zhigang
Zhou, Haijian
Kan, Biao
The Transmission and Antibiotic Resistance Variation in a Multiple Drug Resistance Clade of Vibrio cholerae Circulating in Multiple Countries in Asia
title The Transmission and Antibiotic Resistance Variation in a Multiple Drug Resistance Clade of Vibrio cholerae Circulating in Multiple Countries in Asia
title_full The Transmission and Antibiotic Resistance Variation in a Multiple Drug Resistance Clade of Vibrio cholerae Circulating in Multiple Countries in Asia
title_fullStr The Transmission and Antibiotic Resistance Variation in a Multiple Drug Resistance Clade of Vibrio cholerae Circulating in Multiple Countries in Asia
title_full_unstemmed The Transmission and Antibiotic Resistance Variation in a Multiple Drug Resistance Clade of Vibrio cholerae Circulating in Multiple Countries in Asia
title_short The Transmission and Antibiotic Resistance Variation in a Multiple Drug Resistance Clade of Vibrio cholerae Circulating in Multiple Countries in Asia
title_sort transmission and antibiotic resistance variation in a multiple drug resistance clade of vibrio cholerae circulating in multiple countries in asia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773069/
https://www.ncbi.nlm.nih.gov/pubmed/26930352
http://dx.doi.org/10.1371/journal.pone.0149742
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