Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity

Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate...

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Autores principales: Stasiak, Marta, Boncela, Joanna, Perreau, Corinne, Karamanou, Konstantina, Chatron-Colliet, Aurore, Proult, Isabelle, Przygodzka, Patrycja, Chakravarti, Shukti, Maquart, François-Xavier, Kowalska, M. Anna, Wegrowski, Yanusz, Brézillon, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773148/
https://www.ncbi.nlm.nih.gov/pubmed/26930497
http://dx.doi.org/10.1371/journal.pone.0150226
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author Stasiak, Marta
Boncela, Joanna
Perreau, Corinne
Karamanou, Konstantina
Chatron-Colliet, Aurore
Proult, Isabelle
Przygodzka, Patrycja
Chakravarti, Shukti
Maquart, François-Xavier
Kowalska, M. Anna
Wegrowski, Yanusz
Brézillon, Stéphane
author_facet Stasiak, Marta
Boncela, Joanna
Perreau, Corinne
Karamanou, Konstantina
Chatron-Colliet, Aurore
Proult, Isabelle
Przygodzka, Patrycja
Chakravarti, Shukti
Maquart, François-Xavier
Kowalska, M. Anna
Wegrowski, Yanusz
Brézillon, Stéphane
author_sort Stasiak, Marta
collection PubMed
description Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment.
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spelling pubmed-47731482016-03-07 Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity Stasiak, Marta Boncela, Joanna Perreau, Corinne Karamanou, Konstantina Chatron-Colliet, Aurore Proult, Isabelle Przygodzka, Patrycja Chakravarti, Shukti Maquart, François-Xavier Kowalska, M. Anna Wegrowski, Yanusz Brézillon, Stéphane PLoS One Research Article Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment. Public Library of Science 2016-03-01 /pmc/articles/PMC4773148/ /pubmed/26930497 http://dx.doi.org/10.1371/journal.pone.0150226 Text en © 2016 Stasiak et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Stasiak, Marta
Boncela, Joanna
Perreau, Corinne
Karamanou, Konstantina
Chatron-Colliet, Aurore
Proult, Isabelle
Przygodzka, Patrycja
Chakravarti, Shukti
Maquart, François-Xavier
Kowalska, M. Anna
Wegrowski, Yanusz
Brézillon, Stéphane
Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity
title Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity
title_full Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity
title_fullStr Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity
title_full_unstemmed Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity
title_short Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity
title_sort lumican inhibits snail-induced melanoma cell migration specifically by blocking mmp-14 activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773148/
https://www.ncbi.nlm.nih.gov/pubmed/26930497
http://dx.doi.org/10.1371/journal.pone.0150226
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