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Introduction of the Reliable Estimation of Atopic Dermatitis in ChildHood: Novel, Diagnostic Criteria for Childhood Atopic Dermatitis

PURPOSE: Questionnaire-based diagnostic criteria for atopic dermatitis (AD) have been proposed to detect the major group of AD with flexural dermatitis. We aimed to develop novel, questionnaire-based diagnostic criteria for childhood AD, which can detect more comprehensive AD including non-flexural...

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Autores principales: Lee, Seung-Chul, Bae, Jung Min, Lee, Ho-June, Kim, Hyun Jung, Kim, Byung-Soo, Li, Kapsok, Cho, Jae-We, Park, Chang Ook, Cho, Sang Hyun, Lee, Kwang Hoon, Kim, Do-Won, Park, Chun Wook, Kim, Kyu Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773211/
https://www.ncbi.nlm.nih.gov/pubmed/26922933
http://dx.doi.org/10.4168/aair.2016.8.3.230
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author Lee, Seung-Chul
Bae, Jung Min
Lee, Ho-June
Kim, Hyun Jung
Kim, Byung-Soo
Li, Kapsok
Cho, Jae-We
Park, Chang Ook
Cho, Sang Hyun
Lee, Kwang Hoon
Kim, Do-Won
Park, Chun Wook
Kim, Kyu Han
author_facet Lee, Seung-Chul
Bae, Jung Min
Lee, Ho-June
Kim, Hyun Jung
Kim, Byung-Soo
Li, Kapsok
Cho, Jae-We
Park, Chang Ook
Cho, Sang Hyun
Lee, Kwang Hoon
Kim, Do-Won
Park, Chun Wook
Kim, Kyu Han
author_sort Lee, Seung-Chul
collection PubMed
description PURPOSE: Questionnaire-based diagnostic criteria for atopic dermatitis (AD) have been proposed to detect the major group of AD with flexural dermatitis. We aimed to develop novel, questionnaire-based diagnostic criteria for childhood AD, which can detect more comprehensive AD including non-flexural type. METHODS: The draft version of questionnaire to detect childhood AD was prepared to be used for preliminary hospital- (n=1,756) and community-based (n=1,320) surveys. From analysis, the Reliable Estimation of Atopic dermatitis of ChildHood (REACH) was derived and verified in derivation (n=1,129) and validation (n=1,191) sets by community-based surveys. RESULTS: The REACH consists of 11 questions including 2 major and 9 minor criteria. AD is diagnosed as the major group of 'eczema on the antecubital or popliteal fossa' to fulfill the 2 major criteria (2M), and the minor group of 'eczema on the non-antecubital or popliteal fossa' to fulfill the 1 major plus 4 or more minor criteria (1M+4m). In the validation set, the overall 1-year AD prevalence by the REACH was estimated as 12.3% (95% CI, 10.5%-14.2%), and the REACH showed a sensitivity of 75.2%, a specificity of 96.1%, and an error rate of 6.4%. The REACH demonstrated better diagnostic performance than the ISAAC in terms of the number of misclassification (10.0%). CONCLUSIONS: We propose the REACH as new full, questionnaire-based diagnostic criteria for childhood AD in epidemiological surveys. Further studies are warranted to validate the REACH in different populations or countries in the context of large-scale, epidemiological surveys.
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spelling pubmed-47732112016-05-01 Introduction of the Reliable Estimation of Atopic Dermatitis in ChildHood: Novel, Diagnostic Criteria for Childhood Atopic Dermatitis Lee, Seung-Chul Bae, Jung Min Lee, Ho-June Kim, Hyun Jung Kim, Byung-Soo Li, Kapsok Cho, Jae-We Park, Chang Ook Cho, Sang Hyun Lee, Kwang Hoon Kim, Do-Won Park, Chun Wook Kim, Kyu Han Allergy Asthma Immunol Res Original Article PURPOSE: Questionnaire-based diagnostic criteria for atopic dermatitis (AD) have been proposed to detect the major group of AD with flexural dermatitis. We aimed to develop novel, questionnaire-based diagnostic criteria for childhood AD, which can detect more comprehensive AD including non-flexural type. METHODS: The draft version of questionnaire to detect childhood AD was prepared to be used for preliminary hospital- (n=1,756) and community-based (n=1,320) surveys. From analysis, the Reliable Estimation of Atopic dermatitis of ChildHood (REACH) was derived and verified in derivation (n=1,129) and validation (n=1,191) sets by community-based surveys. RESULTS: The REACH consists of 11 questions including 2 major and 9 minor criteria. AD is diagnosed as the major group of 'eczema on the antecubital or popliteal fossa' to fulfill the 2 major criteria (2M), and the minor group of 'eczema on the non-antecubital or popliteal fossa' to fulfill the 1 major plus 4 or more minor criteria (1M+4m). In the validation set, the overall 1-year AD prevalence by the REACH was estimated as 12.3% (95% CI, 10.5%-14.2%), and the REACH showed a sensitivity of 75.2%, a specificity of 96.1%, and an error rate of 6.4%. The REACH demonstrated better diagnostic performance than the ISAAC in terms of the number of misclassification (10.0%). CONCLUSIONS: We propose the REACH as new full, questionnaire-based diagnostic criteria for childhood AD in epidemiological surveys. Further studies are warranted to validate the REACH in different populations or countries in the context of large-scale, epidemiological surveys. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2016-05 2015-12-08 /pmc/articles/PMC4773211/ /pubmed/26922933 http://dx.doi.org/10.4168/aair.2016.8.3.230 Text en Copyright © 2016 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Seung-Chul
Bae, Jung Min
Lee, Ho-June
Kim, Hyun Jung
Kim, Byung-Soo
Li, Kapsok
Cho, Jae-We
Park, Chang Ook
Cho, Sang Hyun
Lee, Kwang Hoon
Kim, Do-Won
Park, Chun Wook
Kim, Kyu Han
Introduction of the Reliable Estimation of Atopic Dermatitis in ChildHood: Novel, Diagnostic Criteria for Childhood Atopic Dermatitis
title Introduction of the Reliable Estimation of Atopic Dermatitis in ChildHood: Novel, Diagnostic Criteria for Childhood Atopic Dermatitis
title_full Introduction of the Reliable Estimation of Atopic Dermatitis in ChildHood: Novel, Diagnostic Criteria for Childhood Atopic Dermatitis
title_fullStr Introduction of the Reliable Estimation of Atopic Dermatitis in ChildHood: Novel, Diagnostic Criteria for Childhood Atopic Dermatitis
title_full_unstemmed Introduction of the Reliable Estimation of Atopic Dermatitis in ChildHood: Novel, Diagnostic Criteria for Childhood Atopic Dermatitis
title_short Introduction of the Reliable Estimation of Atopic Dermatitis in ChildHood: Novel, Diagnostic Criteria for Childhood Atopic Dermatitis
title_sort introduction of the reliable estimation of atopic dermatitis in childhood: novel, diagnostic criteria for childhood atopic dermatitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773211/
https://www.ncbi.nlm.nih.gov/pubmed/26922933
http://dx.doi.org/10.4168/aair.2016.8.3.230
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