Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta

Activation of the wnt signaling pathway is a major cause of colon cancer development. Tankyrase inhibitors (TNKSi) have recently been developed to block the wnt pathway by increasing axin levels to promote degradation of the wnt-regulator β-catenin. TNKSi bind to the PARP (poly(ADP)ribose polymerase...

Descripción completa

Detalles Bibliográficos
Autores principales: Martino-Echarri, Estefania, Brocardo, Mariana G., Mills, Kate M., Henderson, Beric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773256/
https://www.ncbi.nlm.nih.gov/pubmed/26930278
http://dx.doi.org/10.1371/journal.pone.0150484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773256/
https://www.ncbi.nlm.nih.gov/pubmed/26930278
http://dx.doi.org/10.1371/journal.pone.0150484

Ejemplares similares