Cargando…

Structural dataset for the fast-exchanging KRAS G13D

Cancers bearing the KRAS G13D mutation are notable for their distinct clinical behavior relative to other oncogenic KRAS mutations. We hypothesized that primary biochemical or biophysical properties of KRAS G13D might contribute to these clinical observations and as part of our study undertook struc...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Jia, Hunter, John, Manandhar, Anuj, Gurbani, Deepak, Westover, Kenneth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773362/
https://www.ncbi.nlm.nih.gov/pubmed/26958611
http://dx.doi.org/10.1016/j.dib.2015.10.001
_version_ 1782418721627701248
author Lu, Jia
Hunter, John
Manandhar, Anuj
Gurbani, Deepak
Westover, Kenneth D.
author_facet Lu, Jia
Hunter, John
Manandhar, Anuj
Gurbani, Deepak
Westover, Kenneth D.
author_sort Lu, Jia
collection PubMed
description Cancers bearing the KRAS G13D mutation are notable for their distinct clinical behavior relative to other oncogenic KRAS mutations. We hypothesized that primary biochemical or biophysical properties of KRAS G13D might contribute to these clinical observations and as part of our study undertook structural studies using x-ray crystallography. In this data article we discuss several x-ray diffraction datasets that yielded structures of oncogenic KRAS mutants including a high resolution (1.13 Å) structure of KRAS G13D. The datasets are typical for high resolution x-ray diffraction data and allow the construction of atomic resolution, three dimensional structural models with high confidence. This data can be correlated with biochemical information such as defects in substrate binding kinetics, GTPase activities and interactions with the RAS effector RAF kinase.
format Online
Article
Text
id pubmed-4773362
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-47733622016-03-08 Structural dataset for the fast-exchanging KRAS G13D Lu, Jia Hunter, John Manandhar, Anuj Gurbani, Deepak Westover, Kenneth D. Data Brief Data Article Cancers bearing the KRAS G13D mutation are notable for their distinct clinical behavior relative to other oncogenic KRAS mutations. We hypothesized that primary biochemical or biophysical properties of KRAS G13D might contribute to these clinical observations and as part of our study undertook structural studies using x-ray crystallography. In this data article we discuss several x-ray diffraction datasets that yielded structures of oncogenic KRAS mutants including a high resolution (1.13 Å) structure of KRAS G13D. The datasets are typical for high resolution x-ray diffraction data and allow the construction of atomic resolution, three dimensional structural models with high confidence. This data can be correlated with biochemical information such as defects in substrate binding kinetics, GTPase activities and interactions with the RAS effector RAF kinase. Elsevier 2015-10-17 /pmc/articles/PMC4773362/ /pubmed/26958611 http://dx.doi.org/10.1016/j.dib.2015.10.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Lu, Jia
Hunter, John
Manandhar, Anuj
Gurbani, Deepak
Westover, Kenneth D.
Structural dataset for the fast-exchanging KRAS G13D
title Structural dataset for the fast-exchanging KRAS G13D
title_full Structural dataset for the fast-exchanging KRAS G13D
title_fullStr Structural dataset for the fast-exchanging KRAS G13D
title_full_unstemmed Structural dataset for the fast-exchanging KRAS G13D
title_short Structural dataset for the fast-exchanging KRAS G13D
title_sort structural dataset for the fast-exchanging kras g13d
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773362/
https://www.ncbi.nlm.nih.gov/pubmed/26958611
http://dx.doi.org/10.1016/j.dib.2015.10.001
work_keys_str_mv AT lujia structuraldatasetforthefastexchangingkrasg13d
AT hunterjohn structuraldatasetforthefastexchangingkrasg13d
AT manandharanuj structuraldatasetforthefastexchangingkrasg13d
AT gurbanideepak structuraldatasetforthefastexchangingkrasg13d
AT westoverkennethd structuraldatasetforthefastexchangingkrasg13d