Cargando…
Comparison of the aggregation of homologous β(2)-microglobulin variants reveals protein solubility as a key determinant of amyloid formation
The mouse and human β(2)-microglobulin protein orthologs are 70 % identical in sequence and share 88 % sequence similarity. These proteins are predicted by various algorithms to have similar aggregation and amyloid propensities. However, whilst human β(2)m (hβ(2)m) forms amyloid-like fibrils in dena...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773402/ https://www.ncbi.nlm.nih.gov/pubmed/26780548 http://dx.doi.org/10.1016/j.jmb.2016.01.009 |