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Data set in support of neurotoxicity of trimethyltin chloride by morphological and protein analysis
Trimethyltin chloride (TMT) is a neurotoxicant widely present in the aquatic environment. Chronic exposure of embryos to TMT for 4 days post-fertilization (dpf) elicited a concentration-related decrease in head & eye size and increase in axial malformation. In addition, Rohon-Beard sensory neuro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773414/ https://www.ncbi.nlm.nih.gov/pubmed/26958629 http://dx.doi.org/10.1016/j.dib.2016.01.021 |
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author | Kim, C-Yoon Kim, Jin Song, Juha Oh, Hanseul Park, Jae-Hak |
author_facet | Kim, C-Yoon Kim, Jin Song, Juha Oh, Hanseul Park, Jae-Hak |
author_sort | Kim, C-Yoon |
collection | PubMed |
description | Trimethyltin chloride (TMT) is a neurotoxicant widely present in the aquatic environment. Chronic exposure of embryos to TMT for 4 days post-fertilization (dpf) elicited a concentration-related decrease in head & eye size and increase in axial malformation. In addition, Rohon-Beard sensory neurons and motor neurons showed decreased patterns of protein expression. These data coincide with previous research about the neurotoxicity of TMT on mRNA expression (Kim et al., 2016 [1]). These data demonstrates that TMT inhibits specific neurodevelopmental stages in zebrafish embryos and suggests a possible mechanism for the toxicity of TMT in vertebrate neurodevelopment. This paper contains data related to research concurrently published in Kim et al. (2016) [1]. |
format | Online Article Text |
id | pubmed-4773414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-47734142016-03-08 Data set in support of neurotoxicity of trimethyltin chloride by morphological and protein analysis Kim, C-Yoon Kim, Jin Song, Juha Oh, Hanseul Park, Jae-Hak Data Brief Data Article Trimethyltin chloride (TMT) is a neurotoxicant widely present in the aquatic environment. Chronic exposure of embryos to TMT for 4 days post-fertilization (dpf) elicited a concentration-related decrease in head & eye size and increase in axial malformation. In addition, Rohon-Beard sensory neurons and motor neurons showed decreased patterns of protein expression. These data coincide with previous research about the neurotoxicity of TMT on mRNA expression (Kim et al., 2016 [1]). These data demonstrates that TMT inhibits specific neurodevelopmental stages in zebrafish embryos and suggests a possible mechanism for the toxicity of TMT in vertebrate neurodevelopment. This paper contains data related to research concurrently published in Kim et al. (2016) [1]. Elsevier 2016-01-16 /pmc/articles/PMC4773414/ /pubmed/26958629 http://dx.doi.org/10.1016/j.dib.2016.01.021 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Data Article Kim, C-Yoon Kim, Jin Song, Juha Oh, Hanseul Park, Jae-Hak Data set in support of neurotoxicity of trimethyltin chloride by morphological and protein analysis |
title | Data set in support of neurotoxicity of trimethyltin chloride by morphological and protein analysis |
title_full | Data set in support of neurotoxicity of trimethyltin chloride by morphological and protein analysis |
title_fullStr | Data set in support of neurotoxicity of trimethyltin chloride by morphological and protein analysis |
title_full_unstemmed | Data set in support of neurotoxicity of trimethyltin chloride by morphological and protein analysis |
title_short | Data set in support of neurotoxicity of trimethyltin chloride by morphological and protein analysis |
title_sort | data set in support of neurotoxicity of trimethyltin chloride by morphological and protein analysis |
topic | Data Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773414/ https://www.ncbi.nlm.nih.gov/pubmed/26958629 http://dx.doi.org/10.1016/j.dib.2016.01.021 |
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