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RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
Recent high-throughput studies revealed recurrent RUNX1 mutations in breast cancer, specifically in oestrogen receptor-positive (ER(+)) tumours. However, mechanisms underlying the implied RUNX1-mediated tumour suppression remain elusive. Here, by depleting mammary epithelial cells of RUNX1 in vivo a...
Autores principales: | Chimge, Nyam-Osor, Little, Gillian H., Baniwal, Sanjeev K., Adisetiyo, Helty, Xie, Ying, Zhang, Tian, O'Laughlin, Andie, Liu, Zhi Y., Ulrich, Peaches, Martin, Anthony, Mhawech-Fauceglia, Paulette, Ellis, Matthew J., Tripathy, Debu, Groshen, Susan, Liang, Chengyu, Li, Zhe, Schones, Dustin E., Frenkel, Baruch |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773428/ https://www.ncbi.nlm.nih.gov/pubmed/26916619 http://dx.doi.org/10.1038/ncomms10751 |
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