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Single-Unit Muscle Sympathetic Nerve Activity Reflects Sleep Apnea Severity, Especially in Severe Obstructive Sleep Apnea Patients
Obstructive sleep apnea syndrome (OSAS) is associated with augmented sympathetic nerve activity, as assessed by multi-unit muscle sympathetic nerve activity (MSNA). However, it is still unclear whether single-unit MSNA is a better reflection of sleep apnea severity according to the apnea-hypopnea in...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773439/ https://www.ncbi.nlm.nih.gov/pubmed/26973534 http://dx.doi.org/10.3389/fphys.2016.00066 |
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author | Hamaoka, Takuto Murai, Hisayoshi Kaneko, Shuichi Usui, Soichiro Okabe, Yoshitaka Tokuhisa, Hideki Kato, Takeshi Furusho, Hiroshi Sugiyama, Yu Nakatsumi, Yasuto Takata, Shigeo Takamura, Masayuki |
author_facet | Hamaoka, Takuto Murai, Hisayoshi Kaneko, Shuichi Usui, Soichiro Okabe, Yoshitaka Tokuhisa, Hideki Kato, Takeshi Furusho, Hiroshi Sugiyama, Yu Nakatsumi, Yasuto Takata, Shigeo Takamura, Masayuki |
author_sort | Hamaoka, Takuto |
collection | PubMed |
description | Obstructive sleep apnea syndrome (OSAS) is associated with augmented sympathetic nerve activity, as assessed by multi-unit muscle sympathetic nerve activity (MSNA). However, it is still unclear whether single-unit MSNA is a better reflection of sleep apnea severity according to the apnea-hypopnea index (AHI). One hundred and two OSAS patients underwent full polysomnography and single- and multi-unit MSNA measurements. Univariate and multivariate regression analysis were performed to determine which parameters correlated with OSAS severity, which was defined by the AHI. Single- and multi-unit MSNA were significantly and positively correlated with AHI severity. The AHI was also significantly correlated with multi-unit MSNA burst frequency (r = 0.437, p < 0.0001) and single-unit MSNA spike frequency (r = 0.632, p < 0.0001). Multivariable analysis revealed that SF was correlated most significantly with AHI (T = 7.27, p < 0.0001). The distributions of multiple single-unit spikes per one cardiac interval did not differ between patients with an AHI of <30 and those with and AHI of 30–55 events/h; however, the pattern of each multiple spike firing were significantly higher in patients with an AHI of >55. These results suggest that sympathetic nerve activity is associated with sleep apnea severity. In addition, single-unit MSNA is a more accurate reflection of sleep apnea severity with alternation of the firing pattern, especially in patients with very severe OSAS. |
format | Online Article Text |
id | pubmed-4773439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47734392016-03-11 Single-Unit Muscle Sympathetic Nerve Activity Reflects Sleep Apnea Severity, Especially in Severe Obstructive Sleep Apnea Patients Hamaoka, Takuto Murai, Hisayoshi Kaneko, Shuichi Usui, Soichiro Okabe, Yoshitaka Tokuhisa, Hideki Kato, Takeshi Furusho, Hiroshi Sugiyama, Yu Nakatsumi, Yasuto Takata, Shigeo Takamura, Masayuki Front Physiol Physiology Obstructive sleep apnea syndrome (OSAS) is associated with augmented sympathetic nerve activity, as assessed by multi-unit muscle sympathetic nerve activity (MSNA). However, it is still unclear whether single-unit MSNA is a better reflection of sleep apnea severity according to the apnea-hypopnea index (AHI). One hundred and two OSAS patients underwent full polysomnography and single- and multi-unit MSNA measurements. Univariate and multivariate regression analysis were performed to determine which parameters correlated with OSAS severity, which was defined by the AHI. Single- and multi-unit MSNA were significantly and positively correlated with AHI severity. The AHI was also significantly correlated with multi-unit MSNA burst frequency (r = 0.437, p < 0.0001) and single-unit MSNA spike frequency (r = 0.632, p < 0.0001). Multivariable analysis revealed that SF was correlated most significantly with AHI (T = 7.27, p < 0.0001). The distributions of multiple single-unit spikes per one cardiac interval did not differ between patients with an AHI of <30 and those with and AHI of 30–55 events/h; however, the pattern of each multiple spike firing were significantly higher in patients with an AHI of >55. These results suggest that sympathetic nerve activity is associated with sleep apnea severity. In addition, single-unit MSNA is a more accurate reflection of sleep apnea severity with alternation of the firing pattern, especially in patients with very severe OSAS. Frontiers Media S.A. 2016-03-02 /pmc/articles/PMC4773439/ /pubmed/26973534 http://dx.doi.org/10.3389/fphys.2016.00066 Text en Copyright © 2016 Hamaoka, Murai, Kaneko, Usui, Okabe, Tokuhisa, Kato, Furusho, Sugiyama, Nakatsumi, Takata and Takamura. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Hamaoka, Takuto Murai, Hisayoshi Kaneko, Shuichi Usui, Soichiro Okabe, Yoshitaka Tokuhisa, Hideki Kato, Takeshi Furusho, Hiroshi Sugiyama, Yu Nakatsumi, Yasuto Takata, Shigeo Takamura, Masayuki Single-Unit Muscle Sympathetic Nerve Activity Reflects Sleep Apnea Severity, Especially in Severe Obstructive Sleep Apnea Patients |
title | Single-Unit Muscle Sympathetic Nerve Activity Reflects Sleep Apnea Severity, Especially in Severe Obstructive Sleep Apnea Patients |
title_full | Single-Unit Muscle Sympathetic Nerve Activity Reflects Sleep Apnea Severity, Especially in Severe Obstructive Sleep Apnea Patients |
title_fullStr | Single-Unit Muscle Sympathetic Nerve Activity Reflects Sleep Apnea Severity, Especially in Severe Obstructive Sleep Apnea Patients |
title_full_unstemmed | Single-Unit Muscle Sympathetic Nerve Activity Reflects Sleep Apnea Severity, Especially in Severe Obstructive Sleep Apnea Patients |
title_short | Single-Unit Muscle Sympathetic Nerve Activity Reflects Sleep Apnea Severity, Especially in Severe Obstructive Sleep Apnea Patients |
title_sort | single-unit muscle sympathetic nerve activity reflects sleep apnea severity, especially in severe obstructive sleep apnea patients |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773439/ https://www.ncbi.nlm.nih.gov/pubmed/26973534 http://dx.doi.org/10.3389/fphys.2016.00066 |
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