Cargando…
Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph no...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773445/ https://www.ncbi.nlm.nih.gov/pubmed/26915335 http://dx.doi.org/10.1038/ncomms10875 |
_version_ | 1782418740882702336 |
---|---|
author | Vu Van, Dana Beier, Katja C. Pietzke, Lea-Jean Al Baz, Maysun S. Feist, Randi K. Gurka, Stephanie Hamelmann, Eckard Kroczek, Richard A. Hutloff, Andreas |
author_facet | Vu Van, Dana Beier, Katja C. Pietzke, Lea-Jean Al Baz, Maysun S. Feist, Randi K. Gurka, Stephanie Hamelmann, Eckard Kroczek, Richard A. Hutloff, Andreas |
author_sort | Vu Van, Dana |
collection | PubMed |
description | Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph node. In the lung we identify a B-cell population exhibiting a classical germinal centre phenotype without being organized into ectopic lymphoid tissue. By contrast, classical CXCR5(+) Bcl-6(+) T follicular helper cells are not present. Nevertheless, lung-infiltrating T cells exhibit follicular helper-like properties including the potential to provide help to naive B cells. The lung tissue is also a survival niche for memory T and B cells remaining in residual peribronchial infiltrates after resolution of inflammation. Collectively, this study shows the importance of T/B cooperation not only in lymph nodes but also in inflamed peripheral tissues for local antibody responses to infection and autoimmunity. |
format | Online Article Text |
id | pubmed-4773445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47734452016-03-04 Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells Vu Van, Dana Beier, Katja C. Pietzke, Lea-Jean Al Baz, Maysun S. Feist, Randi K. Gurka, Stephanie Hamelmann, Eckard Kroczek, Richard A. Hutloff, Andreas Nat Commun Article Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph node. In the lung we identify a B-cell population exhibiting a classical germinal centre phenotype without being organized into ectopic lymphoid tissue. By contrast, classical CXCR5(+) Bcl-6(+) T follicular helper cells are not present. Nevertheless, lung-infiltrating T cells exhibit follicular helper-like properties including the potential to provide help to naive B cells. The lung tissue is also a survival niche for memory T and B cells remaining in residual peribronchial infiltrates after resolution of inflammation. Collectively, this study shows the importance of T/B cooperation not only in lymph nodes but also in inflamed peripheral tissues for local antibody responses to infection and autoimmunity. Nature Publishing Group 2016-02-26 /pmc/articles/PMC4773445/ /pubmed/26915335 http://dx.doi.org/10.1038/ncomms10875 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Vu Van, Dana Beier, Katja C. Pietzke, Lea-Jean Al Baz, Maysun S. Feist, Randi K. Gurka, Stephanie Hamelmann, Eckard Kroczek, Richard A. Hutloff, Andreas Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells |
title | Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells |
title_full | Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells |
title_fullStr | Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells |
title_full_unstemmed | Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells |
title_short | Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells |
title_sort | local t/b cooperation in inflamed tissues is supported by t follicular helper-like cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773445/ https://www.ncbi.nlm.nih.gov/pubmed/26915335 http://dx.doi.org/10.1038/ncomms10875 |
work_keys_str_mv | AT vuvandana localtbcooperationininflamedtissuesissupportedbytfollicularhelperlikecells AT beierkatjac localtbcooperationininflamedtissuesissupportedbytfollicularhelperlikecells AT pietzkeleajean localtbcooperationininflamedtissuesissupportedbytfollicularhelperlikecells AT albazmaysuns localtbcooperationininflamedtissuesissupportedbytfollicularhelperlikecells AT feistrandik localtbcooperationininflamedtissuesissupportedbytfollicularhelperlikecells AT gurkastephanie localtbcooperationininflamedtissuesissupportedbytfollicularhelperlikecells AT hamelmanneckard localtbcooperationininflamedtissuesissupportedbytfollicularhelperlikecells AT kroczekricharda localtbcooperationininflamedtissuesissupportedbytfollicularhelperlikecells AT hutloffandreas localtbcooperationininflamedtissuesissupportedbytfollicularhelperlikecells |