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Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells

Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph no...

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Autores principales: Vu Van, Dana, Beier, Katja C., Pietzke, Lea-Jean, Al Baz, Maysun S., Feist, Randi K., Gurka, Stephanie, Hamelmann, Eckard, Kroczek, Richard A., Hutloff, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773445/
https://www.ncbi.nlm.nih.gov/pubmed/26915335
http://dx.doi.org/10.1038/ncomms10875
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author Vu Van, Dana
Beier, Katja C.
Pietzke, Lea-Jean
Al Baz, Maysun S.
Feist, Randi K.
Gurka, Stephanie
Hamelmann, Eckard
Kroczek, Richard A.
Hutloff, Andreas
author_facet Vu Van, Dana
Beier, Katja C.
Pietzke, Lea-Jean
Al Baz, Maysun S.
Feist, Randi K.
Gurka, Stephanie
Hamelmann, Eckard
Kroczek, Richard A.
Hutloff, Andreas
author_sort Vu Van, Dana
collection PubMed
description Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph node. In the lung we identify a B-cell population exhibiting a classical germinal centre phenotype without being organized into ectopic lymphoid tissue. By contrast, classical CXCR5(+) Bcl-6(+) T follicular helper cells are not present. Nevertheless, lung-infiltrating T cells exhibit follicular helper-like properties including the potential to provide help to naive B cells. The lung tissue is also a survival niche for memory T and B cells remaining in residual peribronchial infiltrates after resolution of inflammation. Collectively, this study shows the importance of T/B cooperation not only in lymph nodes but also in inflamed peripheral tissues for local antibody responses to infection and autoimmunity.
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spelling pubmed-47734452016-03-04 Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells Vu Van, Dana Beier, Katja C. Pietzke, Lea-Jean Al Baz, Maysun S. Feist, Randi K. Gurka, Stephanie Hamelmann, Eckard Kroczek, Richard A. Hutloff, Andreas Nat Commun Article Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph node. In the lung we identify a B-cell population exhibiting a classical germinal centre phenotype without being organized into ectopic lymphoid tissue. By contrast, classical CXCR5(+) Bcl-6(+) T follicular helper cells are not present. Nevertheless, lung-infiltrating T cells exhibit follicular helper-like properties including the potential to provide help to naive B cells. The lung tissue is also a survival niche for memory T and B cells remaining in residual peribronchial infiltrates after resolution of inflammation. Collectively, this study shows the importance of T/B cooperation not only in lymph nodes but also in inflamed peripheral tissues for local antibody responses to infection and autoimmunity. Nature Publishing Group 2016-02-26 /pmc/articles/PMC4773445/ /pubmed/26915335 http://dx.doi.org/10.1038/ncomms10875 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Vu Van, Dana
Beier, Katja C.
Pietzke, Lea-Jean
Al Baz, Maysun S.
Feist, Randi K.
Gurka, Stephanie
Hamelmann, Eckard
Kroczek, Richard A.
Hutloff, Andreas
Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
title Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
title_full Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
title_fullStr Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
title_full_unstemmed Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
title_short Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
title_sort local t/b cooperation in inflamed tissues is supported by t follicular helper-like cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773445/
https://www.ncbi.nlm.nih.gov/pubmed/26915335
http://dx.doi.org/10.1038/ncomms10875
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