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Estimation of the Mechanism of Adrenal Action of Endocrine-Disrupting Compounds Using a Computational Model of Adrenal Steroidogenesis in NCI-H295R Cells

Adrenal toxicity is one of the major concerns in drug development. To quantitatively understand the effect of endocrine-active compounds on adrenal steroidogenesis and to assess the human adrenal toxicity of novel pharmaceutical drugs, we developed a mathematical model of steroidogenesis in human ad...

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Detalles Bibliográficos
Autores principales:	Saito, Ryuta, Terasaki, Natsuko, Yamazaki, Makoto, Masutomi, Naoya, Tsutsui, Naohisa, Okamoto, Masahiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773560/ https://www.ncbi.nlm.nih.gov/pubmed/27057163 http://dx.doi.org/10.1155/2016/4041827

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