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Genetics of cardiovascular and renal complications in diabetes
The development of debilitating complications represents a major heathcare burden associated with the treatment of diabetes. Despite advances in new therapies for controlling hyperglycemia, the burden associated with diabetic complications remains high, especially in relation to cardiovascular and r...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773661/ https://www.ncbi.nlm.nih.gov/pubmed/27042264 http://dx.doi.org/10.1111/jdi.12391 |
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author | Ma, Ronald CW |
author_facet | Ma, Ronald CW |
author_sort | Ma, Ronald CW |
collection | PubMed |
description | The development of debilitating complications represents a major heathcare burden associated with the treatment of diabetes. Despite advances in new therapies for controlling hyperglycemia, the burden associated with diabetic complications remains high, especially in relation to cardiovascular and renal complications. Furthermore, an increasing proportion of patients develop type 2 diabetes at a younger age, putting them at higher risk of developing complications as a result of the increased exposure to hyperglycemia. Diabetes has become the main contributing cause to end‐stage renal disease in most countries. Although there has been important breakthroughs in our understanding of the genetics of type 1 and type 2 diabetes, bringing important insights towards the pathogenesis of diabetes, there has been comparatively less progress in our understanding of the genetic basis of diabetic complications. Genome‐wide association studies are beginning to expand our understanding of the genetic architecture relating to diabetic complications. Improved understanding of the genetic basis of diabetic cardiorenal complications might provide an opportunity for improved risk prediction, as well as the development of new therapies. |
format | Online Article Text |
id | pubmed-4773661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47736612016-04-01 Genetics of cardiovascular and renal complications in diabetes Ma, Ronald CW J Diabetes Investig Review Articles The development of debilitating complications represents a major heathcare burden associated with the treatment of diabetes. Despite advances in new therapies for controlling hyperglycemia, the burden associated with diabetic complications remains high, especially in relation to cardiovascular and renal complications. Furthermore, an increasing proportion of patients develop type 2 diabetes at a younger age, putting them at higher risk of developing complications as a result of the increased exposure to hyperglycemia. Diabetes has become the main contributing cause to end‐stage renal disease in most countries. Although there has been important breakthroughs in our understanding of the genetics of type 1 and type 2 diabetes, bringing important insights towards the pathogenesis of diabetes, there has been comparatively less progress in our understanding of the genetic basis of diabetic complications. Genome‐wide association studies are beginning to expand our understanding of the genetic architecture relating to diabetic complications. Improved understanding of the genetic basis of diabetic cardiorenal complications might provide an opportunity for improved risk prediction, as well as the development of new therapies. John Wiley and Sons Inc. 2015-08-26 2016-03 /pmc/articles/PMC4773661/ /pubmed/27042264 http://dx.doi.org/10.1111/jdi.12391 Text en © 2015 The Author. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Articles Ma, Ronald CW Genetics of cardiovascular and renal complications in diabetes |
title | Genetics of cardiovascular and renal complications in diabetes |
title_full | Genetics of cardiovascular and renal complications in diabetes |
title_fullStr | Genetics of cardiovascular and renal complications in diabetes |
title_full_unstemmed | Genetics of cardiovascular and renal complications in diabetes |
title_short | Genetics of cardiovascular and renal complications in diabetes |
title_sort | genetics of cardiovascular and renal complications in diabetes |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773661/ https://www.ncbi.nlm.nih.gov/pubmed/27042264 http://dx.doi.org/10.1111/jdi.12391 |
work_keys_str_mv | AT maronaldcw geneticsofcardiovascularandrenalcomplicationsindiabetes |