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Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry

BACKGROUND/AIMS: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and o...

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Autores principales: Park, So Young, Lee, Sang Min, Shin, Jong Wook, Choi, Byoung Whui, Kim, Hojoong, Lee, Jae Seung, Lee, Sang Do, Park, Sung Soo, Moon, Hwa Sik, Park, Yong Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773708/
https://www.ncbi.nlm.nih.gov/pubmed/26689916
http://dx.doi.org/10.3904/kjim.2014.122
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author Park, So Young
Lee, Sang Min
Shin, Jong Wook
Choi, Byoung Whui
Kim, Hojoong
Lee, Jae Seung
Lee, Sang Do
Park, Sung Soo
Moon, Hwa Sik
Park, Yong Bum
author_facet Park, So Young
Lee, Sang Min
Shin, Jong Wook
Choi, Byoung Whui
Kim, Hojoong
Lee, Jae Seung
Lee, Sang Do
Park, Sung Soo
Moon, Hwa Sik
Park, Yong Bum
author_sort Park, So Young
collection PubMed
description BACKGROUND/AIMS: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and outcomes of CTEPH in a Korean cohort. METHODS: This study included South Korean patients diagnosed with CTEPH between September 2008 and October 2011. Baseline characteristics, treatments and outcomes were analyzed. RESULTS: A total of 134 patients were included in this study with 76 females (56.7%). Their median age was 58.3 ± 15.9 years and dyspnea (112 patients, 83.5%) was the most common presenting symptom. Sixty-three patients (47%) had a history of acute pulmonary embolism or deep vein thrombosis, and six (4.5%) had pulmonary tuberculosis. In total, 28 patients (21%) underwent pulmonary thromboendarterectomy (PTE), and 99 patients had medical therapy. During the study period, 18 patients (13.4%) died. In a multivariate analysis, higher hemoglobin (relative risk [RR], 1.516; 95% confidence interval [CI], 1.053 to 2.184; p = 0.025) and lower total cholesterol levels (RR, 0.982; 95% CI, 0.965 to 0.999; p = 0.037) were associated with increased mortality. CONCLUSIONS: This was the first national cohort study of Korean patients with CTEPH. Accurate diagnosis, characterization and distributions of CTEPH are imperative for prompt treatment in patients, particularly those undergoing PTE.
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spelling pubmed-47737082016-03-03 Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry Park, So Young Lee, Sang Min Shin, Jong Wook Choi, Byoung Whui Kim, Hojoong Lee, Jae Seung Lee, Sang Do Park, Sung Soo Moon, Hwa Sik Park, Yong Bum Korean J Intern Med Original Article BACKGROUND/AIMS: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and outcomes of CTEPH in a Korean cohort. METHODS: This study included South Korean patients diagnosed with CTEPH between September 2008 and October 2011. Baseline characteristics, treatments and outcomes were analyzed. RESULTS: A total of 134 patients were included in this study with 76 females (56.7%). Their median age was 58.3 ± 15.9 years and dyspnea (112 patients, 83.5%) was the most common presenting symptom. Sixty-three patients (47%) had a history of acute pulmonary embolism or deep vein thrombosis, and six (4.5%) had pulmonary tuberculosis. In total, 28 patients (21%) underwent pulmonary thromboendarterectomy (PTE), and 99 patients had medical therapy. During the study period, 18 patients (13.4%) died. In a multivariate analysis, higher hemoglobin (relative risk [RR], 1.516; 95% confidence interval [CI], 1.053 to 2.184; p = 0.025) and lower total cholesterol levels (RR, 0.982; 95% CI, 0.965 to 0.999; p = 0.037) were associated with increased mortality. CONCLUSIONS: This was the first national cohort study of Korean patients with CTEPH. Accurate diagnosis, characterization and distributions of CTEPH are imperative for prompt treatment in patients, particularly those undergoing PTE. The Korean Association of Internal Medicine 2016-03 2016-01-27 /pmc/articles/PMC4773708/ /pubmed/26689916 http://dx.doi.org/10.3904/kjim.2014.122 Text en Copyright © 2016 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, So Young
Lee, Sang Min
Shin, Jong Wook
Choi, Byoung Whui
Kim, Hojoong
Lee, Jae Seung
Lee, Sang Do
Park, Sung Soo
Moon, Hwa Sik
Park, Yong Bum
Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
title Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
title_full Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
title_fullStr Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
title_full_unstemmed Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
title_short Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
title_sort epidemiology of chronic thromboembolic pulmonary hypertension in korea: results from the korean registry
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773708/
https://www.ncbi.nlm.nih.gov/pubmed/26689916
http://dx.doi.org/10.3904/kjim.2014.122
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