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Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry
BACKGROUND/AIMS: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and o...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Internal Medicine
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773708/ https://www.ncbi.nlm.nih.gov/pubmed/26689916 http://dx.doi.org/10.3904/kjim.2014.122 |
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author | Park, So Young Lee, Sang Min Shin, Jong Wook Choi, Byoung Whui Kim, Hojoong Lee, Jae Seung Lee, Sang Do Park, Sung Soo Moon, Hwa Sik Park, Yong Bum |
author_facet | Park, So Young Lee, Sang Min Shin, Jong Wook Choi, Byoung Whui Kim, Hojoong Lee, Jae Seung Lee, Sang Do Park, Sung Soo Moon, Hwa Sik Park, Yong Bum |
author_sort | Park, So Young |
collection | PubMed |
description | BACKGROUND/AIMS: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and outcomes of CTEPH in a Korean cohort. METHODS: This study included South Korean patients diagnosed with CTEPH between September 2008 and October 2011. Baseline characteristics, treatments and outcomes were analyzed. RESULTS: A total of 134 patients were included in this study with 76 females (56.7%). Their median age was 58.3 ± 15.9 years and dyspnea (112 patients, 83.5%) was the most common presenting symptom. Sixty-three patients (47%) had a history of acute pulmonary embolism or deep vein thrombosis, and six (4.5%) had pulmonary tuberculosis. In total, 28 patients (21%) underwent pulmonary thromboendarterectomy (PTE), and 99 patients had medical therapy. During the study period, 18 patients (13.4%) died. In a multivariate analysis, higher hemoglobin (relative risk [RR], 1.516; 95% confidence interval [CI], 1.053 to 2.184; p = 0.025) and lower total cholesterol levels (RR, 0.982; 95% CI, 0.965 to 0.999; p = 0.037) were associated with increased mortality. CONCLUSIONS: This was the first national cohort study of Korean patients with CTEPH. Accurate diagnosis, characterization and distributions of CTEPH are imperative for prompt treatment in patients, particularly those undergoing PTE. |
format | Online Article Text |
id | pubmed-4773708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-47737082016-03-03 Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry Park, So Young Lee, Sang Min Shin, Jong Wook Choi, Byoung Whui Kim, Hojoong Lee, Jae Seung Lee, Sang Do Park, Sung Soo Moon, Hwa Sik Park, Yong Bum Korean J Intern Med Original Article BACKGROUND/AIMS: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and outcomes of CTEPH in a Korean cohort. METHODS: This study included South Korean patients diagnosed with CTEPH between September 2008 and October 2011. Baseline characteristics, treatments and outcomes were analyzed. RESULTS: A total of 134 patients were included in this study with 76 females (56.7%). Their median age was 58.3 ± 15.9 years and dyspnea (112 patients, 83.5%) was the most common presenting symptom. Sixty-three patients (47%) had a history of acute pulmonary embolism or deep vein thrombosis, and six (4.5%) had pulmonary tuberculosis. In total, 28 patients (21%) underwent pulmonary thromboendarterectomy (PTE), and 99 patients had medical therapy. During the study period, 18 patients (13.4%) died. In a multivariate analysis, higher hemoglobin (relative risk [RR], 1.516; 95% confidence interval [CI], 1.053 to 2.184; p = 0.025) and lower total cholesterol levels (RR, 0.982; 95% CI, 0.965 to 0.999; p = 0.037) were associated with increased mortality. CONCLUSIONS: This was the first national cohort study of Korean patients with CTEPH. Accurate diagnosis, characterization and distributions of CTEPH are imperative for prompt treatment in patients, particularly those undergoing PTE. The Korean Association of Internal Medicine 2016-03 2016-01-27 /pmc/articles/PMC4773708/ /pubmed/26689916 http://dx.doi.org/10.3904/kjim.2014.122 Text en Copyright © 2016 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, So Young Lee, Sang Min Shin, Jong Wook Choi, Byoung Whui Kim, Hojoong Lee, Jae Seung Lee, Sang Do Park, Sung Soo Moon, Hwa Sik Park, Yong Bum Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry |
title | Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry |
title_full | Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry |
title_fullStr | Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry |
title_full_unstemmed | Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry |
title_short | Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry |
title_sort | epidemiology of chronic thromboembolic pulmonary hypertension in korea: results from the korean registry |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773708/ https://www.ncbi.nlm.nih.gov/pubmed/26689916 http://dx.doi.org/10.3904/kjim.2014.122 |
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