The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection

Brucella species are the most important zoonotic pathogens worldwide and cause considerable harm to humans and animals. In this study, we presented the complete genome of B. suis 019 isolated from sheep (ovine) with epididymitis. B. suis 019 has a rough phenotype and can infect sheep, rhesus monkeys...

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Detalles Bibliográficos
Autores principales: Wang, Yuanzhi, Wang, Zhen, Chen, Xin, Zhang, Hui, Guo, Fei, Zhang, Ke, Feng, Hanping, Gu, Wenyi, Wu, Changxin, Ma, Lei, Li, Tiansen, Chen, Chuangfu, Gao, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773751/
https://www.ncbi.nlm.nih.gov/pubmed/26821047
http://dx.doi.org/10.3390/genes7020007
Descripción
Sumario:Brucella species are the most important zoonotic pathogens worldwide and cause considerable harm to humans and animals. In this study, we presented the complete genome of B. suis 019 isolated from sheep (ovine) with epididymitis. B. suis 019 has a rough phenotype and can infect sheep, rhesus monkeys and possibly humans. The comparative genome analysis demonstrated that B. suis 019 is closest to the vaccine strain B. suis bv. 1 str. S2. Further analysis associated the rsh gene to the pathogenicity of B. suis 019, and the WbkA gene to the rough phenotype of B. suis 019. The 019 complete genome data was deposited in the GenBank database with ID PRJNA308608.

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