The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection

Brucella species are the most important zoonotic pathogens worldwide and cause considerable harm to humans and animals. In this study, we presented the complete genome of B. suis 019 isolated from sheep (ovine) with epididymitis. B. suis 019 has a rough phenotype and can infect sheep, rhesus monkeys...

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Autores principales: Wang, Yuanzhi, Wang, Zhen, Chen, Xin, Zhang, Hui, Guo, Fei, Zhang, Ke, Feng, Hanping, Gu, Wenyi, Wu, Changxin, Ma, Lei, Li, Tiansen, Chen, Chuangfu, Gao, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773751/
https://www.ncbi.nlm.nih.gov/pubmed/26821047
http://dx.doi.org/10.3390/genes7020007
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author Wang, Yuanzhi
Wang, Zhen
Chen, Xin
Zhang, Hui
Guo, Fei
Zhang, Ke
Feng, Hanping
Gu, Wenyi
Wu, Changxin
Ma, Lei
Li, Tiansen
Chen, Chuangfu
Gao, Shan
author_facet Wang, Yuanzhi
Wang, Zhen
Chen, Xin
Zhang, Hui
Guo, Fei
Zhang, Ke
Feng, Hanping
Gu, Wenyi
Wu, Changxin
Ma, Lei
Li, Tiansen
Chen, Chuangfu
Gao, Shan
author_sort Wang, Yuanzhi
collection PubMed
description Brucella species are the most important zoonotic pathogens worldwide and cause considerable harm to humans and animals. In this study, we presented the complete genome of B. suis 019 isolated from sheep (ovine) with epididymitis. B. suis 019 has a rough phenotype and can infect sheep, rhesus monkeys and possibly humans. The comparative genome analysis demonstrated that B. suis 019 is closest to the vaccine strain B. suis bv. 1 str. S2. Further analysis associated the rsh gene to the pathogenicity of B. suis 019, and the WbkA gene to the rough phenotype of B. suis 019. The 019 complete genome data was deposited in the GenBank database with ID PRJNA308608.
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spelling pubmed-47737512016-03-09 The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection Wang, Yuanzhi Wang, Zhen Chen, Xin Zhang, Hui Guo, Fei Zhang, Ke Feng, Hanping Gu, Wenyi Wu, Changxin Ma, Lei Li, Tiansen Chen, Chuangfu Gao, Shan Genes (Basel) Article Brucella species are the most important zoonotic pathogens worldwide and cause considerable harm to humans and animals. In this study, we presented the complete genome of B. suis 019 isolated from sheep (ovine) with epididymitis. B. suis 019 has a rough phenotype and can infect sheep, rhesus monkeys and possibly humans. The comparative genome analysis demonstrated that B. suis 019 is closest to the vaccine strain B. suis bv. 1 str. S2. Further analysis associated the rsh gene to the pathogenicity of B. suis 019, and the WbkA gene to the rough phenotype of B. suis 019. The 019 complete genome data was deposited in the GenBank database with ID PRJNA308608. MDPI 2016-01-26 /pmc/articles/PMC4773751/ /pubmed/26821047 http://dx.doi.org/10.3390/genes7020007 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Yuanzhi
Wang, Zhen
Chen, Xin
Zhang, Hui
Guo, Fei
Zhang, Ke
Feng, Hanping
Gu, Wenyi
Wu, Changxin
Ma, Lei
Li, Tiansen
Chen, Chuangfu
Gao, Shan
The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection
title The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection
title_full The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection
title_fullStr The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection
title_full_unstemmed The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection
title_short The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection
title_sort complete genome of brucella suis 019 provides insights on cross-species infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773751/
https://www.ncbi.nlm.nih.gov/pubmed/26821047
http://dx.doi.org/10.3390/genes7020007
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