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Epithelial-Mesenchymal Transition and Breast Cancer
Breast cancer is the most common cancer in women and distant site metastasis is the main cause of death in breast cancer patients. There is increasing evidence supporting the role of epithelial-mesenchymal transition (EMT) in tumor cell progression, invasion, and metastasis. During the process of EM...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773769/ https://www.ncbi.nlm.nih.gov/pubmed/26821054 http://dx.doi.org/10.3390/jcm5020013 |
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author | Wu, Yanyuan Sarkissyan, Marianna Vadgama, Jaydutt V. |
author_facet | Wu, Yanyuan Sarkissyan, Marianna Vadgama, Jaydutt V. |
author_sort | Wu, Yanyuan |
collection | PubMed |
description | Breast cancer is the most common cancer in women and distant site metastasis is the main cause of death in breast cancer patients. There is increasing evidence supporting the role of epithelial-mesenchymal transition (EMT) in tumor cell progression, invasion, and metastasis. During the process of EMT, epithelial cancer cells acquire molecular alternations that facilitate the loss of epithelial features and gain of mesenchymal phenotype. Such transformation promotes cancer cell migration and invasion. Moreover, emerging evidence suggests that EMT is associated with the increased enrichment of cancer stem-like cells (CSCs) and these CSCs display mesenchymal characteristics that are resistant to chemotherapy and target therapy. However, the clinical relevance of EMT in human cancer is still under debate. This review will provide an overview of current evidence of EMT from studies using clinical human breast cancer tissues and its associated challenges. |
format | Online Article Text |
id | pubmed-4773769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-47737692016-03-03 Epithelial-Mesenchymal Transition and Breast Cancer Wu, Yanyuan Sarkissyan, Marianna Vadgama, Jaydutt V. J Clin Med Review Breast cancer is the most common cancer in women and distant site metastasis is the main cause of death in breast cancer patients. There is increasing evidence supporting the role of epithelial-mesenchymal transition (EMT) in tumor cell progression, invasion, and metastasis. During the process of EMT, epithelial cancer cells acquire molecular alternations that facilitate the loss of epithelial features and gain of mesenchymal phenotype. Such transformation promotes cancer cell migration and invasion. Moreover, emerging evidence suggests that EMT is associated with the increased enrichment of cancer stem-like cells (CSCs) and these CSCs display mesenchymal characteristics that are resistant to chemotherapy and target therapy. However, the clinical relevance of EMT in human cancer is still under debate. This review will provide an overview of current evidence of EMT from studies using clinical human breast cancer tissues and its associated challenges. MDPI 2016-01-26 /pmc/articles/PMC4773769/ /pubmed/26821054 http://dx.doi.org/10.3390/jcm5020013 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wu, Yanyuan Sarkissyan, Marianna Vadgama, Jaydutt V. Epithelial-Mesenchymal Transition and Breast Cancer |
title | Epithelial-Mesenchymal Transition and Breast Cancer |
title_full | Epithelial-Mesenchymal Transition and Breast Cancer |
title_fullStr | Epithelial-Mesenchymal Transition and Breast Cancer |
title_full_unstemmed | Epithelial-Mesenchymal Transition and Breast Cancer |
title_short | Epithelial-Mesenchymal Transition and Breast Cancer |
title_sort | epithelial-mesenchymal transition and breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773769/ https://www.ncbi.nlm.nih.gov/pubmed/26821054 http://dx.doi.org/10.3390/jcm5020013 |
work_keys_str_mv | AT wuyanyuan epithelialmesenchymaltransitionandbreastcancer AT sarkissyanmarianna epithelialmesenchymaltransitionandbreastcancer AT vadgamajayduttv epithelialmesenchymaltransitionandbreastcancer |