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Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease
The epicardium is an epithelial monolayer that plays a central role in heart development and the myocardial response to injury. Recent developments in our understanding of epicardial cell biology have revealed this layer to be a dynamic participant in fundamental processes underlying the development...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773783/ https://www.ncbi.nlm.nih.gov/pubmed/26907357 http://dx.doi.org/10.3390/jcm5020027 |
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author | Krainock, Michael Toubat, Omar Danopoulos, Soula Beckham, Allison Warburton, David Kim, Richard |
author_facet | Krainock, Michael Toubat, Omar Danopoulos, Soula Beckham, Allison Warburton, David Kim, Richard |
author_sort | Krainock, Michael |
collection | PubMed |
description | The epicardium is an epithelial monolayer that plays a central role in heart development and the myocardial response to injury. Recent developments in our understanding of epicardial cell biology have revealed this layer to be a dynamic participant in fundamental processes underlying the development of the embryonic ventricles, the coronary vasculature, and the cardiac valves. Likewise, recent data have identified the epicardium as an important contributor to reparative and regenerative processes in the injured myocardium. These essential functions of the epicardium rely on both non-cell autonomous and cell-autonomous mechanisms, with the latter featuring the process of epicardial Epithelial-to-Mesenchymal Transition (EMT). This review will focus on the induction and regulation of epicardial EMT, as it pertains to both cardiogenesis and the response of the myocardium to injury. |
format | Online Article Text |
id | pubmed-4773783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-47737832016-03-03 Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease Krainock, Michael Toubat, Omar Danopoulos, Soula Beckham, Allison Warburton, David Kim, Richard J Clin Med Review The epicardium is an epithelial monolayer that plays a central role in heart development and the myocardial response to injury. Recent developments in our understanding of epicardial cell biology have revealed this layer to be a dynamic participant in fundamental processes underlying the development of the embryonic ventricles, the coronary vasculature, and the cardiac valves. Likewise, recent data have identified the epicardium as an important contributor to reparative and regenerative processes in the injured myocardium. These essential functions of the epicardium rely on both non-cell autonomous and cell-autonomous mechanisms, with the latter featuring the process of epicardial Epithelial-to-Mesenchymal Transition (EMT). This review will focus on the induction and regulation of epicardial EMT, as it pertains to both cardiogenesis and the response of the myocardium to injury. MDPI 2016-02-19 /pmc/articles/PMC4773783/ /pubmed/26907357 http://dx.doi.org/10.3390/jcm5020027 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Krainock, Michael Toubat, Omar Danopoulos, Soula Beckham, Allison Warburton, David Kim, Richard Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease |
title | Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease |
title_full | Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease |
title_fullStr | Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease |
title_full_unstemmed | Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease |
title_short | Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease |
title_sort | epicardial epithelial-to-mesenchymal transition in heart development and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773783/ https://www.ncbi.nlm.nih.gov/pubmed/26907357 http://dx.doi.org/10.3390/jcm5020027 |
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