Diminished but Not Abolished Effect of Two His351 Mutants of Anthrax Edema Factor in a Murine Model

Edema toxin (ET), which is composed of a potent adenylate cyclase (AC), edema factor (EF), and protective antigen (PA), is one of the major toxicity factors of Bacillus anthracis. In this study, we introduced mutations in full-length EF to generate alanine EF(H351A) and arginine EF(H351R) variants....

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Detalles Bibliográficos
Autores principales: Zhao, Taoran, Zhao, Xinghui, Liu, Ju, Meng, Yingying, Feng, Yingying, Fang, Ting, Zhang, Jinlong, Yang, Xiuxu, Li, Jianmin, Xu, Junjie, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773788/
https://www.ncbi.nlm.nih.gov/pubmed/26848687
http://dx.doi.org/10.3390/toxins8020035

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