Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer

BACKGROUND: Breast cancer comprises clinically and molecularly distinct tumor subgroups that differ in cell histology and biology and show divergent clinical phenotypes that impede phase III trials, such as those utilizing cathepsin K inhibitors. Here we correlate the epithelial-mesenchymal-like tra...

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Detalles Bibliográficos
Autores principales: Andrade, Sheila Siqueira, Gouvea, Iuri Estrada, Silva, Mariana Cristina C., Castro, Eloísa Dognani, de Paula, Cláudia A. A., Okamoto, Debora, Oliveira, Lilian, Peres, Giovani Bravin, Ottaiano, Tatiana, Facina, Gil, Nazário, Afonso Celso Pinto, Campos, Antonio Hugo J. F. M., Paredes-Gamero, Edgar Julian, Juliano, Maria, da Silva, Ismael D. C. G., Oliva, Maria Luiza V., Girão, Manoel J. B. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774035/
https://www.ncbi.nlm.nih.gov/pubmed/26931461
http://dx.doi.org/10.1186/s12885-016-2203-7

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