Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state

Fibroblast growth factor (FGF) 15/19 and FGF21 are two atypical members of FGF19 subfamily that function as hormones. Exogenous FGF15/19 and FGF21 have pharmacological effects, and endogenous FGF15/19 and FGF21 play vital roles in the maintenance of energy homeostasis. Recent reports have expanded t...

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Detalles Bibliográficos
Autores principales: Guan, Dandan, Zhao, Lidan, Chen, Daiwen, Yu, Bing, Yu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774037/
https://www.ncbi.nlm.nih.gov/pubmed/26931208
http://dx.doi.org/10.1186/s12967-016-0821-0
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author Guan, Dandan
Zhao, Lidan
Chen, Daiwen
Yu, Bing
Yu, Jie
author_facet Guan, Dandan
Zhao, Lidan
Chen, Daiwen
Yu, Bing
Yu, Jie
author_sort Guan, Dandan
collection PubMed
description Fibroblast growth factor (FGF) 15/19 and FGF21 are two atypical members of FGF19 subfamily that function as hormones. Exogenous FGF15/19 and FGF21 have pharmacological effects, and endogenous FGF15/19 and FGF21 play vital roles in the maintenance of energy homeostasis. Recent reports have expanded the effects of FGF15/19 and FGF21 on carbohydrate and lipid metabolism. However, the regulations of FGF15/19 and FGF21 on metabolism are different. FGF15/19 is mainly secreted from the small intestine in response to feeding, and FGF21 is secreted from the liver in response to extended fasting and from the liver and adipose tissue in response to feeding. In this work, we reviewed the regulatory effects of FGF15/19 and FGF21 on metabolism in the fast and fed states. This information may provide some insight into the metabolic regulation of FGF15/19 and FGF21 in different physiological condition.
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spelling pubmed-47740372016-03-03 Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state Guan, Dandan Zhao, Lidan Chen, Daiwen Yu, Bing Yu, Jie J Transl Med Review Fibroblast growth factor (FGF) 15/19 and FGF21 are two atypical members of FGF19 subfamily that function as hormones. Exogenous FGF15/19 and FGF21 have pharmacological effects, and endogenous FGF15/19 and FGF21 play vital roles in the maintenance of energy homeostasis. Recent reports have expanded the effects of FGF15/19 and FGF21 on carbohydrate and lipid metabolism. However, the regulations of FGF15/19 and FGF21 on metabolism are different. FGF15/19 is mainly secreted from the small intestine in response to feeding, and FGF21 is secreted from the liver in response to extended fasting and from the liver and adipose tissue in response to feeding. In this work, we reviewed the regulatory effects of FGF15/19 and FGF21 on metabolism in the fast and fed states. This information may provide some insight into the metabolic regulation of FGF15/19 and FGF21 in different physiological condition. BioMed Central 2016-03-01 /pmc/articles/PMC4774037/ /pubmed/26931208 http://dx.doi.org/10.1186/s12967-016-0821-0 Text en © Guan et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Guan, Dandan
Zhao, Lidan
Chen, Daiwen
Yu, Bing
Yu, Jie
Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
title Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
title_full Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
title_fullStr Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
title_full_unstemmed Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
title_short Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
title_sort regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774037/
https://www.ncbi.nlm.nih.gov/pubmed/26931208
http://dx.doi.org/10.1186/s12967-016-0821-0
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