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Cyclophilin A (CypA) Plays Dual Roles in Regulation of Bone Anabolism and Resorption

CypA (Cyclophilin A) is a peptidyl-prolyl isomerase previously shown to be required for chondrogenic differentiation and endochondral ossification. However, the effects of CypA on osteoclast activity and bone maintenance are entirely unknown. Here, we show that Ppia(−/−) mice demonstrate low bone mi...

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Detalles Bibliográficos
Autores principales:	Guo, Mian, James, Aaron W., Kwak, Jin Hee, Shen, Jia, Yokoyama, Kazunari K., Ting, Kang, Soo, Chia B., Chiu, Robert H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774113/ https://www.ncbi.nlm.nih.gov/pubmed/26932182 http://dx.doi.org/10.1038/srep22378

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