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Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents

AIM: The present study was performed to investigate acute and subchronic oral toxicity of Ferula assa-foetida gum (28 days) in Sprague Dawley rats. MATERIALS AND METHODS: Acute oral administration of F. assa-foetida was done as a single bolus dose up to 5 g/kg in mice and subchronic toxicity study f...

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Autores principales: Goudah, Ayman, Abdo-El-Sooud, Khaled, Yousef, Manal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Veterinary World 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774717/
https://www.ncbi.nlm.nih.gov/pubmed/27047139
http://dx.doi.org/10.14202/vetworld.2015.584-589
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author Goudah, Ayman
Abdo-El-Sooud, Khaled
Yousef, Manal A.
author_facet Goudah, Ayman
Abdo-El-Sooud, Khaled
Yousef, Manal A.
author_sort Goudah, Ayman
collection PubMed
description AIM: The present study was performed to investigate acute and subchronic oral toxicity of Ferula assa-foetida gum (28 days) in Sprague Dawley rats. MATERIALS AND METHODS: Acute oral administration of F. assa-foetida was done as a single bolus dose up to 5 g/kg in mice and subchronic toxicity study for 28 days was done by oral administration at doses of 0 (control) and 250 mg/kg in Sprague Dawley rats. RESULTS: The obtained data revealed that oral administration of F. assa-foetida extract in rats for 28 successive days had no significant changes on body weight, body weight gain, the hematological parameters in rats all over the period of the experiment, and there are no significant increases in the activity of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatinine and urea. Liver of treated rats showed mild changes as thrombosis and sinusoidal leukocytosis. It also showed portal infiltration with inflammatory cells, while kidney of treated rat showed an atrophy of glomerular tuft, thickening of parietal layer of Bowman capsule, and focal tubular necrosis. It also showed dilatation and congestion of renal blood vessels. CONCLUSION: We concluded that F. assa-foetida gum had broad safety and little toxicity for short term use in dose of 250 mg/kg.
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spelling pubmed-47747172016-04-04 Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents Goudah, Ayman Abdo-El-Sooud, Khaled Yousef, Manal A. Vet World Research Article AIM: The present study was performed to investigate acute and subchronic oral toxicity of Ferula assa-foetida gum (28 days) in Sprague Dawley rats. MATERIALS AND METHODS: Acute oral administration of F. assa-foetida was done as a single bolus dose up to 5 g/kg in mice and subchronic toxicity study for 28 days was done by oral administration at doses of 0 (control) and 250 mg/kg in Sprague Dawley rats. RESULTS: The obtained data revealed that oral administration of F. assa-foetida extract in rats for 28 successive days had no significant changes on body weight, body weight gain, the hematological parameters in rats all over the period of the experiment, and there are no significant increases in the activity of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatinine and urea. Liver of treated rats showed mild changes as thrombosis and sinusoidal leukocytosis. It also showed portal infiltration with inflammatory cells, while kidney of treated rat showed an atrophy of glomerular tuft, thickening of parietal layer of Bowman capsule, and focal tubular necrosis. It also showed dilatation and congestion of renal blood vessels. CONCLUSION: We concluded that F. assa-foetida gum had broad safety and little toxicity for short term use in dose of 250 mg/kg. Veterinary World 2015-05 2015-05-06 /pmc/articles/PMC4774717/ /pubmed/27047139 http://dx.doi.org/10.14202/vetworld.2015.584-589 Text en Copyright: © The authors. http://creativecommons.org/licenses/by/2.0 This article is an open access article licensed under the terms of the Creative Commons Attributin License (http://creative commons.org/licenses/by/2.0) which permits unrestricted use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Research Article
Goudah, Ayman
Abdo-El-Sooud, Khaled
Yousef, Manal A.
Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents
title Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents
title_full Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents
title_fullStr Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents
title_full_unstemmed Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents
title_short Acute and subchronic toxicity assessment model of Ferula assa-foetida gum in rodents
title_sort acute and subchronic toxicity assessment model of ferula assa-foetida gum in rodents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774717/
https://www.ncbi.nlm.nih.gov/pubmed/27047139
http://dx.doi.org/10.14202/vetworld.2015.584-589
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