Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats

AIM: The present study was performed to investigate the effect of Phyllanthus amarus extracts on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats. MATERIALS AND METHODS: Pancreatic cancer was developed in Wistar rats by intraperitoneal administration of azaserine (canc...

Descripción completa

Detalles Bibliográficos
Autores principales: Prajapati, Ankit S., Raval, Sunant K., Sinha, Suprita, Varia, Tapan N., Mashiyava, Parimal H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Veterinary World 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774759/
https://www.ncbi.nlm.nih.gov/pubmed/27047180
http://dx.doi.org/10.14202/vetworld.2015.937-940
Descripción
Sumario:AIM: The present study was performed to investigate the effect of Phyllanthus amarus extracts on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats. MATERIALS AND METHODS: Pancreatic cancer was developed in Wistar rats by intraperitoneal administration of azaserine (cancer inducer) for 21 days at the concentration of 5 mg/kg body weight. Aqueous and alcoholic extracts were given to rats of different groups as per protocol. RESULTS: The results data revealed that oral administration of P. amarus extracts had a significant change in pancreatic amylase, lipase, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activity. CONCLUSION: We concluded that extract of P. amarus possessed chemoprotective activity against azaserine induced pancreatic cancer in Wistar rats.

Ejemplares similares