Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats

AIM: The present study was performed to investigate the effect of Phyllanthus amarus extracts on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats. MATERIALS AND METHODS: Pancreatic cancer was developed in Wistar rats by intraperitoneal administration of azaserine (canc...

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Detalles Bibliográficos
Autores principales: Prajapati, Ankit S., Raval, Sunant K., Sinha, Suprita, Varia, Tapan N., Mashiyava, Parimal H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Veterinary World 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774759/
https://www.ncbi.nlm.nih.gov/pubmed/27047180
http://dx.doi.org/10.14202/vetworld.2015.937-940
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author Prajapati, Ankit S.
Raval, Sunant K.
Sinha, Suprita
Varia, Tapan N.
Mashiyava, Parimal H.
author_facet Prajapati, Ankit S.
Raval, Sunant K.
Sinha, Suprita
Varia, Tapan N.
Mashiyava, Parimal H.
author_sort Prajapati, Ankit S.
collection PubMed
description AIM: The present study was performed to investigate the effect of Phyllanthus amarus extracts on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats. MATERIALS AND METHODS: Pancreatic cancer was developed in Wistar rats by intraperitoneal administration of azaserine (cancer inducer) for 21 days at the concentration of 5 mg/kg body weight. Aqueous and alcoholic extracts were given to rats of different groups as per protocol. RESULTS: The results data revealed that oral administration of P. amarus extracts had a significant change in pancreatic amylase, lipase, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activity. CONCLUSION: We concluded that extract of P. amarus possessed chemoprotective activity against azaserine induced pancreatic cancer in Wistar rats.
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spelling pubmed-47747592016-04-04 Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats Prajapati, Ankit S. Raval, Sunant K. Sinha, Suprita Varia, Tapan N. Mashiyava, Parimal H. Vet World Research Article AIM: The present study was performed to investigate the effect of Phyllanthus amarus extracts on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats. MATERIALS AND METHODS: Pancreatic cancer was developed in Wistar rats by intraperitoneal administration of azaserine (cancer inducer) for 21 days at the concentration of 5 mg/kg body weight. Aqueous and alcoholic extracts were given to rats of different groups as per protocol. RESULTS: The results data revealed that oral administration of P. amarus extracts had a significant change in pancreatic amylase, lipase, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activity. CONCLUSION: We concluded that extract of P. amarus possessed chemoprotective activity against azaserine induced pancreatic cancer in Wistar rats. Veterinary World 2015-08 2015-08-07 /pmc/articles/PMC4774759/ /pubmed/27047180 http://dx.doi.org/10.14202/vetworld.2015.937-940 Text en Copyright: © The authors. http://creativecommons.org/licenses/by/2.0 This article is an open access article licensed under the terms of the Creative Commons Attributin License (http://creative commons.org/licenses/by/2.0) which permits unrestricted use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Research Article
Prajapati, Ankit S.
Raval, Sunant K.
Sinha, Suprita
Varia, Tapan N.
Mashiyava, Parimal H.
Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats
title Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats
title_full Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats
title_fullStr Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats
title_full_unstemmed Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats
title_short Effect of Phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in Wistar rats
title_sort effect of phyllanthus amarus on serum biochemical changes in azaserine induced pancreatic cancer in wistar rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774759/
https://www.ncbi.nlm.nih.gov/pubmed/27047180
http://dx.doi.org/10.14202/vetworld.2015.937-940
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